No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon

Martin P. Grobusch; Julian J. Gabor; John J. Aponte; Norbert G. Schwarz; Marc Poetschke; Jenny Doernemann; Katharina Schuster; Kai B. Koester; Katharina Profanter; Lea B. Borchert; Florian Kurth; Peter Pongratz; Saadou Issifou; Bertrand Lell; Peter G. Kremsner

doi:https://doi.org/10.1086/647990

No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon

Martin P. Grobusch, Julian J. Gabor, John J. Aponte, Norbert G. Schwarz, Marc Poetschke, Jenny Doernemann, Katharina Schuster, Kai B. Koester, Katharina Profanter, Lea B. Borchert, Florian Kurth, Peter Pongratz, Saadou Issifou, Bertrand Lell, Peter G. Kremsner

Infectious diseases (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18-30 months were followed up after having received their last dose at an age of 15 months. In the intention-to-treat population, the protective efficacy against all malaria episodes was -18.0 (95% confidence interval, -97.4 to 29.5; P = .529). The protective efficacy against first or only anemia episode was -45.3 (95% confidence interval, -234.5 to 36.3; P=.375). The protective efficacies were negative and were not statistically significant. These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants. Clinical trials registration. NCT00167843

Original language	English
Pages (from-to)	1658-1661
Journal	Journal of infectious diseases
Volume	200
Issue number	11
DOIs	https://doi.org/10.1086/647990
Publication status	Published - 2009

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https://doi.org/10.1086/647990

Cite this

Grobusch, M. P., Gabor, J. J., Aponte, J. J., Schwarz, N. G., Poetschke, M., Doernemann, J., Schuster, K., Koester, K. B., Profanter, K., Borchert, L. B., Kurth, F., Pongratz, P., Issifou, S., Lell, B., & Kremsner, P. G. (2009). No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon. Journal of infectious diseases, 200(11), 1658-1661. https://doi.org/10.1086/647990

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title = "No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon",

abstract = "In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambar{\'e}n{\'e}, Gabon, children aged 18-30 months were followed up after having received their last dose at an age of 15 months. In the intention-to-treat population, the protective efficacy against all malaria episodes was -18.0 (95% confidence interval, -97.4 to 29.5; P = .529). The protective efficacy against first or only anemia episode was -45.3 (95% confidence interval, -234.5 to 36.3; P=.375). The protective efficacies were negative and were not statistically significant. These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants. Clinical trials registration. NCT00167843",

author = "Grobusch, {Martin P.} and Gabor, {Julian J.} and Aponte, {John J.} and Schwarz, {Norbert G.} and Marc Poetschke and Jenny Doernemann and Katharina Schuster and Koester, {Kai B.} and Katharina Profanter and Borchert, {Lea B.} and Florian Kurth and Peter Pongratz and Saadou Issifou and Bertrand Lell and Kremsner, {Peter G.}",

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Grobusch, MP, Gabor, JJ, Aponte, JJ, Schwarz, NG, Poetschke, M, Doernemann, J, Schuster, K, Koester, KB, Profanter, K, Borchert, LB, Kurth, F, Pongratz, P, Issifou, S, Lell, B & Kremsner, PG 2009, 'No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon', Journal of infectious diseases, vol. 200, no. 11, pp. 1658-1661. https://doi.org/10.1086/647990

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T1 - No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon

AU - Grobusch, Martin P.

AU - Gabor, Julian J.

AU - Aponte, John J.

AU - Schwarz, Norbert G.

AU - Poetschke, Marc

AU - Doernemann, Jenny

AU - Schuster, Katharina

AU - Koester, Kai B.

AU - Profanter, Katharina

AU - Borchert, Lea B.

AU - Kurth, Florian

AU - Pongratz, Peter

AU - Issifou, Saadou

AU - Lell, Bertrand

AU - Kremsner, Peter G.

PY - 2009

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