TY - JOUR
T1 - Nodal metastasis and survival in oral cancer
T2 - Association with protein expression of SLPI, not with LCN2, TACSTD2, or THBS2
AU - Noorlag, Rob
AU - Van Der Groep, Petra
AU - Leusink, Frank K. J.
AU - Van Hooff, Sander R.
AU - Frank, Michaël H.
AU - Willems, Stefan M.
AU - Van Es, Robert J. J.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background Gene expression profiling revealed a strong signature predicting lymph node metastases in oral squamous cell carcinoma (OSCC). Four of the most predictive genes are secretory leukocyte protease inhibitor (SLPI), lipocalin-2 (LCN2), thrombospondin-2 (THBS2), and tumor-associated calcium signal transducer 2 (TACSTD2). This study correlates their protein expression with lymph node metastases, overall survival (OS), and disease-specific survival (DSS). Methods Two hundred twelve patients with OSCC were included for protein expression analysis by immunohistochemistry. Results SLPI expression correlates with lymph node metastases in the whole cohort, not in a subgroup of cT1 to 2N0. SLPI expression correlates with OS (hazard ratio [HR] = 0.61) and DSS (HR = 0.47) in multivariate analysis. LCN2, THBS2, and TACSTD2 show no correlation with lymph node metastases, OS, or DSS. Conclusion Although SLPI expression correlates with lymph node metastases, it has no additional value in determining lymph node metastases in early oral cancer. However, it is an independent predictor for both OS and DSS and therefore a relevant prognostic biomarker in OSCC.
AB - Background Gene expression profiling revealed a strong signature predicting lymph node metastases in oral squamous cell carcinoma (OSCC). Four of the most predictive genes are secretory leukocyte protease inhibitor (SLPI), lipocalin-2 (LCN2), thrombospondin-2 (THBS2), and tumor-associated calcium signal transducer 2 (TACSTD2). This study correlates their protein expression with lymph node metastases, overall survival (OS), and disease-specific survival (DSS). Methods Two hundred twelve patients with OSCC were included for protein expression analysis by immunohistochemistry. Results SLPI expression correlates with lymph node metastases in the whole cohort, not in a subgroup of cT1 to 2N0. SLPI expression correlates with OS (hazard ratio [HR] = 0.61) and DSS (HR = 0.47) in multivariate analysis. LCN2, THBS2, and TACSTD2 show no correlation with lymph node metastases, OS, or DSS. Conclusion Although SLPI expression correlates with lymph node metastases, it has no additional value in determining lymph node metastases in early oral cancer. However, it is an independent predictor for both OS and DSS and therefore a relevant prognostic biomarker in OSCC.
UR - http://www.scopus.com/inward/record.url?scp=84948571597&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/hed.23716
DO - https://doi.org/10.1002/hed.23716
M3 - Article
SN - 1043-3074
VL - 37
SP - 1130
EP - 1136
JO - Head and Neck
JF - Head and Neck
IS - 8
ER -