Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study

A. Joosse, E. R. Koomen, M. K. Casparie, R. M. Herings, H. J. Guchelaar, T. Nijsten

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This case-control study investigates the potential chemoprophylactic properties of non-steroidal anti-inflammatory drugs (NSAIDs) on the incidence of cutaneous melanoma (CM). Data were extracted from the Dutch PHARMO pharmacy database and the PALGA pathology database. Cases had a primary CM between 1991 and 2004, were >or=18 years, and were observed for 3 years in PHARMO before diagnosis. Controls were matched for date of birth, gender, and geographical region. NSAIDs and acetylsalicylic acids (ASAs) were analyzed separately. Adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated using multivariable logistic regression, and the results were stratified across gender. A total of 1,318 CM cases and 6,786 controls were eligible to enter the study. CM incidence was not significantly associated with ever ASA use (adjusted OR: 0.92, 95% CI: 0.76-1.12) or ever non-ASA NSAID use (adjusted OR: 1.10, 95% CI: 0.97-1.24). However, continuous use of low-dose ASAs was associated with a significant reduction of CM risk in women (adjusted OR: 0.54, 95% CI: 0.30-0.99) but not in men (OR: 1.01, 95% CI: 0.69-1.47). A significant trend (P=0.04) from no use, non-continuous use to continuous use was observed in women. Continuous use of low-dose ASAs may be associated with a reduced incidence of CM in women, but not in men.
Original languageEnglish
Pages (from-to)2620-2627
Number of pages8
JournalJournal of Investigative Dermatology
Issue number11
Publication statusPublished - 2009


  • Adolescent Adult Aged Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage Aspirin/*administration & dosage Case-Control Studies Databases, Factual Dose-Response Relationship, Drug Female Humans Incidence Logistic Models Male Melanoma/*epidemiology/immunology Middle Aged Multivariate Analysis Netherlands/epidemiology Risk Factors Risk Reduction Behavior Sex Distribution Skin Neoplasms/*epidemiology/immunology Young Adult

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