Non-TH1 cytokines are augmented systematically early in Guillain-Barré syndrome

Rayomand Press; V. Ozenci; M. Kouwenhoven; H. Link

doi:https://doi.org/10.1212/WNL.58.3.476

Non-T_H1 cytokines are augmented systematically early in Guillain-Barré syndrome

Rayomand Press, V. Ozenci, M. Kouwenhoven, H. Link

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Abstract

The T_H1 vs non-T_H1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor α-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T_H1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.

Original language	English
Pages (from-to)	476-478
Number of pages	3
Journal	Neurology
Volume	58
Issue number	3
DOIs	https://doi.org/10.1212/WNL.58.3.476
Publication status	Published - 12 Feb 2002

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title = "Non-TH1 cytokines are augmented systematically early in Guillain-Barr{\'e} syndrome",

abstract = "The TH1 vs non-TH1 cytokine balance in Guillain-Barr{\'e} syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor α-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-TH1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.",

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AU - Press, Rayomand

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AU - Kouwenhoven, M.

AU - Link, H.

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AB - The TH1 vs non-TH1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor α-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-TH1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.

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JO - Neurology

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Non-TH1 cytokines are augmented systematically early in Guillain-Barré syndrome

Abstract

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Non-T_H1 cytokines are augmented systematically early in Guillain-Barré syndrome