Non-TH1 cytokines are augmented systematically early in Guillain-Barré syndrome

Rayomand Press, V. Ozenci, M. Kouwenhoven, H. Link

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33 Citations (Scopus)


The TH1 vs non-TH1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor α-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-TH1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.

Original languageEnglish
Pages (from-to)476-478
Number of pages3
Issue number3
Publication statusPublished - 12 Feb 2002

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