Noninvasive Fetal Blood Group Typing

C. Ellen van der Schoot, Dian Winkelhorst, Frederik B. Clausen

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

12 Citations (Scopus)

Abstract

Noninvasive fetal genotyping for alloantigens of blood cells is indicated in relation to hemolytic disease of the fetus and newborn (HDFN) and fetal neonatal alloimmune thrombocytopenia (FNAIT). In a diagnostic setting it is used in alloimmunized women, to identify whether the fetus is at risk. In a screening setting it is used to identify women at risk for alloimmunization. In this chapter we describe the clinical background of HDFN and FNAIT as well as the currently available possibilities to prevent immunization by antenatal immunoprophylaxis. This will provide insight for which alloantigens noninvasive genotyping assays are relevant. The molecular basis of these antigen systems is described, and an overview is given of the technical approaches and accuracy of noninvasive genotyping assays.
Original languageEnglish
Title of host publicationNoninvasive Prenatal Testing (NIPT): Applied Genomics in Prenatal Screening and Diagnosis
PublisherElsevier
Pages125-156
ISBN (Electronic)9780128141908
ISBN (Print)9780128141892
DOIs
Publication statusPublished - 2018

Publication series

NameNoninvasive Prenatal Testing (NIPT): Applied Genomics in Prenatal Screening and Diagnosis

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