Normal cognitive performance in patients with chronic alcoholism in contrast to patients with Korsakoff's syndrome

Lydia Krabbendam, Pieter Jelle Visser, Mayke M.A. Derix, Frans Verhey, Paul Hofman, Willem Verhoeven, Siegfried Tuinier, Jelle Jolles

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This study investigated which cognitive deficits are associated with chronic alcoholism. Neuropsychological profiles and MRI brain structure volumes of 14 patients with Korsakoff's syndrome, 15 patients with chronic alcoholism, and 16 healthy control subjects were compared. The patients with alcoholism had a normal cognitive performance and normal brain structure volumes. The patients with Korsacoff's syndrome had performance deficits on tests of memory, visuoperceptual, and executive functions, as well as reduced brain structure volumes. The results suggest that the cognitive deficits cannot be ascribed to mere chronic consumption of alcohol. If cognitive deficits are present in patients with chronic alcoholism, this may point to an underlying brain disorder.

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalJournal of neuropsychiatry and clinical neurosciences
Issue number1
Publication statusPublished - 1 Jan 2000

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