TY - JOUR
T1 - Novel Approaches to Control Malaria in Forested Areas of Southeast Asia
AU - von Seidlein, Lorenz
AU - Peto, Thomas J.
AU - Tripura, Rupam
AU - Pell, Christopher
AU - Yeung, Shunmay
AU - Kindermans, Jean Marie
AU - Dondorp, Arjen
AU - Maude, Richard
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019/6
Y1 - 2019/6
N2 - The emergence and spread of drug resistance in the Greater Mekong Subregion (GMS) have added urgency to accelerate malaria elimination while reducing the treatment options. The remaining foci of malaria transmission are often in forests, where vectors tend to bite during daytime and outdoors, thus reducing the effectiveness of insecticide-treated bed nets. Limited periods of exposure suggest that chemoprophylaxis could be a promising strategy to protect forest workers against malaria. Here we discuss three major questions in optimizing malaria chemoprophylaxis for forest workers: which antimalarial drug regimens are most appropriate, how frequently the chemoprophylaxis should be delivered, and how to motivate forest workers to use, and adhere to, malaria prophylaxis.
AB - The emergence and spread of drug resistance in the Greater Mekong Subregion (GMS) have added urgency to accelerate malaria elimination while reducing the treatment options. The remaining foci of malaria transmission are often in forests, where vectors tend to bite during daytime and outdoors, thus reducing the effectiveness of insecticide-treated bed nets. Limited periods of exposure suggest that chemoprophylaxis could be a promising strategy to protect forest workers against malaria. Here we discuss three major questions in optimizing malaria chemoprophylaxis for forest workers: which antimalarial drug regimens are most appropriate, how frequently the chemoprophylaxis should be delivered, and how to motivate forest workers to use, and adhere to, malaria prophylaxis.
KW - Greater Mekong Subregion
KW - Southeast Asia
KW - antimalarial drugs
KW - forest workers
KW - malaria
KW - prophylaxis
UR - http://www.scopus.com/inward/record.url?scp=85065155907&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065155907&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31076353
U2 - https://doi.org/10.1016/j.pt.2019.03.011
DO - https://doi.org/10.1016/j.pt.2019.03.011
M3 - Review article
C2 - 31076353
SN - 1471-4922
VL - 35
SP - 388
EP - 398
JO - Trends in parasitology
JF - Trends in parasitology
IS - 6
ER -