Novel Approaches to Control Malaria in Forested Areas of Southeast Asia

Lorenz von Seidlein, Thomas J. Peto, Rupam Tripura, Christopher Pell, Shunmay Yeung, Jean Marie Kindermans, Arjen Dondorp, Richard Maude

Research output: Contribution to journalReview articleAcademicpeer-review

29 Citations (Scopus)

Abstract

The emergence and spread of drug resistance in the Greater Mekong Subregion (GMS) have added urgency to accelerate malaria elimination while reducing the treatment options. The remaining foci of malaria transmission are often in forests, where vectors tend to bite during daytime and outdoors, thus reducing the effectiveness of insecticide-treated bed nets. Limited periods of exposure suggest that chemoprophylaxis could be a promising strategy to protect forest workers against malaria. Here we discuss three major questions in optimizing malaria chemoprophylaxis for forest workers: which antimalarial drug regimens are most appropriate, how frequently the chemoprophylaxis should be delivered, and how to motivate forest workers to use, and adhere to, malaria prophylaxis.

Original languageEnglish
Pages (from-to)388-398
Number of pages11
JournalTrends in parasitology
Volume35
Issue number6
Early online date7 May 2019
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Greater Mekong Subregion
  • Southeast Asia
  • antimalarial drugs
  • forest workers
  • malaria
  • prophylaxis

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