Novel approaches to target sodium channel trafficking in cardiomyocytes

The cardiac sodium channel Naᵥ1.5, encoded by the SCN5A gene, plays a crucial role in the electrical activity of the heart. Naᵥ1.5 dysfunction can disrupt this process, leading to arrhythmias and sudden cardiac death. Current pharmacological treatments are limited and restoring Naᵥ1.5 function remains a challenge. We investigated new potential strategies aimed at restoring