NR4A nuclear receptors in atherosclerosis and vein-graft disease

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Abstract

Nur77, Nurr1, and NOR-1 form the NR4A subfamily of the nuclear hormone receptor superfamily of transcription factors and have been described in the regulation of differentiation, proliferation, apoptosis, and survival of many different cell types. The expression of NR4A nuclear receptors in vascular pathologies has only recently been revealed, after which studies on the functional involvement of NR4A receptors in vascular disease were initiated. This review summarizes our current view on involvement of Nur77, Nurr1, and NOR-1 in atherosclerotic vascular disease and discusses NR4A function in vascular response to injury
Original languageEnglish
Pages (from-to)105-111
JournalTrends in cardiovascular medicine
Volume17
Issue number3
DOIs
Publication statusPublished - 2007

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