TY - JOUR
T1 - NR4All in the vessel wall
AU - van Tiel, Claudia M.
AU - de Vries, Carlie J. M.
PY - 2012
Y1 - 2012
N2 - A number of nuclear receptors are involved in maintenance of normal vessel wall physiology as well as in pathophysiological processes such as atherosclerosis, restenosis and remodelling. Recent studies revealed a previously unrecognized function of the NR4A subfamily of nuclear receptors as key regulatory proteins in vascular disease. The NR4A subfamily comprises the members Nur77, Nurr1 and NOR-1 and in the current review a comprehensive overview is given of the data supporting functional involvement of these nuclear receptors in three major cell types in vascular (patho)physiology: endothelial cells, smooth muscle cells and monocytes-macrophages. (C) 2011 Elsevier Ltd. All rights reserved
AB - A number of nuclear receptors are involved in maintenance of normal vessel wall physiology as well as in pathophysiological processes such as atherosclerosis, restenosis and remodelling. Recent studies revealed a previously unrecognized function of the NR4A subfamily of nuclear receptors as key regulatory proteins in vascular disease. The NR4A subfamily comprises the members Nur77, Nurr1 and NOR-1 and in the current review a comprehensive overview is given of the data supporting functional involvement of these nuclear receptors in three major cell types in vascular (patho)physiology: endothelial cells, smooth muscle cells and monocytes-macrophages. (C) 2011 Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.jsbmb.2011.01.010
DO - https://doi.org/10.1016/j.jsbmb.2011.01.010
M3 - Review article
C2 - 21277978
SN - 0960-0760
VL - 130
SP - 186
EP - 193
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
IS - 3-5
ER -