TY - JOUR
T1 - NT-pro-BNP is associated with inducible myocardial ischemia in mildly symptomatic type 2 diabetic patients
AU - Wiersma, Jacobijne J.
AU - van der Zee, P. Marc
AU - van Straalen, Jan P.
AU - Fischer, Johan C.
AU - van Eck-Smit, Berthe L. F.
AU - Tijssen, Jan G. P.
AU - Trip, Mieke D.
AU - Piek, Jan J.
AU - Verberne, Hein J.
PY - 2010
Y1 - 2010
N2 - Baseline levels of N-terminal fragment of the brain natriuretic peptide prohormone (NT-pro-BNP) are associated with myocardial ischemia in non-diabetic patients with stable angina pectoris. A total of 281 patients with diabetes mellitus type 2 and stable angina pectoris underwent myocardial perfusion scintigraphy (MPS). Myocardial ischemia on MPS was present in 140 (50%) patients. These ischemic patients had significantly higher NT-pro-BNP levels compared with patients without ischemia: 183 pg/ml (64-324 pg/ml) vs. 88 pg/ml (34-207 pg/ml), respectively (p <0.001). In addition, NT-pro-BNP ≥180 pg/ml was an independent predictor of the presence of myocardial ischemia (OR 2.36, 95%CI 1.40-3.97, p=0.001). Possible confounding factors such as age and creatinine clearance were of no influence on the predictive value in this specific patient population. These findings strengthen the idea that NT-pro-BNP may be of value in the early detection of diabetic patients with hemodynamic significant coronary artery disease
AB - Baseline levels of N-terminal fragment of the brain natriuretic peptide prohormone (NT-pro-BNP) are associated with myocardial ischemia in non-diabetic patients with stable angina pectoris. A total of 281 patients with diabetes mellitus type 2 and stable angina pectoris underwent myocardial perfusion scintigraphy (MPS). Myocardial ischemia on MPS was present in 140 (50%) patients. These ischemic patients had significantly higher NT-pro-BNP levels compared with patients without ischemia: 183 pg/ml (64-324 pg/ml) vs. 88 pg/ml (34-207 pg/ml), respectively (p <0.001). In addition, NT-pro-BNP ≥180 pg/ml was an independent predictor of the presence of myocardial ischemia (OR 2.36, 95%CI 1.40-3.97, p=0.001). Possible confounding factors such as age and creatinine clearance were of no influence on the predictive value in this specific patient population. These findings strengthen the idea that NT-pro-BNP may be of value in the early detection of diabetic patients with hemodynamic significant coronary artery disease
U2 - https://doi.org/10.1016/j.ijcard.2009.10.035
DO - https://doi.org/10.1016/j.ijcard.2009.10.035
M3 - Comment/Letter to the editor
C2 - 19900726
SN - 0167-5273
VL - 145
SP - 295
EP - 296
JO - International journal of cardiology
JF - International journal of cardiology
IS - 2
ER -