TY - JOUR
T1 - Nutritional and behavioral regulators of choice behavior
AU - Mul, Joram D.
AU - La Fleur, Susanne E.
N1 - Publisher Copyright: © 2016 Elsevier Ltd.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Added sugar, often consumed in the form of sweetened beverages, is currently labeled as a big evil that increases our risk to develop obesity, cardiovascular diseases, and diabetes. Only a few decades ago, however, saturated fat received a similar negative label. Instead of singling out one of these factors we here explore how fat and sugar intake interact, thus influencing brain function and behavior. We first review current literature on how free choice during simultaneous fat and sugar consumption increases subsequent overeating and thus the risk of obesity. Next we propose neural mechanisms how simultaneous access to both fat and sugar could promote cross-sentizisation and increase total caloric intake. On the basis of our current knowledge we hypothesize that independent drinking of sugar, before or concurrent with fat intake, enhances subsequent fat-intake and total caloric intake by altering dopamine, opioid, and NPY signaling within a neural circuitry comprising of the central amygdala, the ventral tegmental area, and the nucleus accumbens.
AB - Added sugar, often consumed in the form of sweetened beverages, is currently labeled as a big evil that increases our risk to develop obesity, cardiovascular diseases, and diabetes. Only a few decades ago, however, saturated fat received a similar negative label. Instead of singling out one of these factors we here explore how fat and sugar intake interact, thus influencing brain function and behavior. We first review current literature on how free choice during simultaneous fat and sugar consumption increases subsequent overeating and thus the risk of obesity. Next we propose neural mechanisms how simultaneous access to both fat and sugar could promote cross-sentizisation and increase total caloric intake. On the basis of our current knowledge we hypothesize that independent drinking of sugar, before or concurrent with fat intake, enhances subsequent fat-intake and total caloric intake by altering dopamine, opioid, and NPY signaling within a neural circuitry comprising of the central amygdala, the ventral tegmental area, and the nucleus accumbens.
UR - http://www.scopus.com/inward/record.url?scp=84957096154&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cobeha.2016.01.009
DO - https://doi.org/10.1016/j.cobeha.2016.01.009
M3 - Review article
SN - 2352-1546
VL - 9
SP - 61
EP - 65
JO - Current Opinion in Behavioral Sciences
JF - Current Opinion in Behavioral Sciences
ER -