Abstract
| Original language | English |
|---|---|
| Article number | e12063 |
| Journal | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 11 Aug 2020 |
Keywords
- body mass index
- cerebral atrophy
- fat free mass
- fat mass
- magnetic resonance imaging
- malnutrition
- microbleeds
- mild cognitive impairment
- nutritional status
- white matter hyperintensities
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In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 12, No. 1, e12063, 11.08.2020.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project
T2 - The NUDAD project
AU - Verhaar, Barbara J. H.
AU - de Leeuw, Francisca A.
AU - Doorduijn, Astrid S.
AU - Fieldhouse, Jay L. P.
AU - van de Rest, Ondine
AU - Teunissen, Charlotte E.
AU - van Berckel, Bart N. M.
AU - Barkhof, Frederik
AU - Visser, Marjolein
AU - de van der Schueren, Marian A. E.
AU - Scheltens, Philip
AU - Kester, Maartje I.
AU - Muller, Majon
AU - van der Flier, Wiesje M.
N1 - Funding Information: Information: The NUDAD project is funded by an NWO-FCB grant (project number 057-14-004). BV is appointed on an Amsterdam Cardiovascular Sciences grant and a Stichting Alzheimer Nederland grant.Research of the Alzheimer Center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The clinical database structure was developed with funding from Stichting Dioraphte. Wiesje M van der Flier holds the Pasman chair, is recipient of a donation by stichting Equilibrio, and of a ZonMW Memorabel grant (#733050814). We acknowledge members of the NUDAD project team: Amsterdam University Medical Center ?location VUmc: Wiesje van der Flier, Maartje Kester, Philip Scheltens, Charlotte Teunissen, Marian de van der Schueren, Francisca de Leeuw, Astrid Doorduijn, Heleen Hendriksen, Jay Fieldhouse, Jos? Overbeek, Els Dekkers; Vrije Universiteit Amsterdam: Marjolein Visser; Wageningen University & Research: Ondine van de Rest, Sanne Boesveldt; DSM: Peter van-Dael, Manfred Eggersdorfer; Nutricia Research: John Sijben, Nick van Wijk, Amos Attali, J. Martin Verkuyl, Danielle Counotte; Friesland Campina: Rolf Bos, Cecile Singh-Povel, Martijn Veltkamp, Ellen van den Heuvel. Funding Information: Charlotte E. Teunissen received grants from the European Commission, the Dutch Research Council (ZonMW), Association of Frontotemporal Dementia/Alzheimer's Drug Discovery Foundation, The Weston Brain Institute, Alzheimer Netherlands. Charlotte E. Teunissen has a collaboration contract with ADx Neurosciences, performed contract research or received grants from Probiodrug, Biogen, Esai, Toyama, Janssen prevention center, Boehringer, AxonNeurosciences, Fujirebio, EIP farma, PeopleBio, and Roche. Bart NM van Berckel received research support from ZonMW, AVID radiopharmaceuticals, CTMM, and Janssen Pharmaceuticals. He is a trainer for Piramal and GE. He receives no personal honoraria. Frederik Barkhof is a consultant for Biogen‐Idec, Janssen Alzheimer Immunotherapy, Bayer‐Schering, Merck‐Serono, Roche, Novartis, Genzyme, and Sanofi‐Aventis; has received sponsorship from European Commission–Horizon 2020, National Institute for Health Research–University College London Hospitals Biomedical Research Centre, Scottish Multiple Sclerosis Register, TEVA, Novartis, and Toshiba; and serves on the editorial boards of , and . Philip Scheltens has received consultancy/speaker fees from Lilly, GE Healthcare, Novartis, Sanofi, Nutricia, Probiodrug, Biogen, Roche, Avraham, and EIP Pharma. PS has acquired grant support from GE Healthcare, Danone Research, Piramal, and MERCK. All funding was paid to the institution. Wiesje M van der Flier received grants from ZonMW, the Food cognition and behavior program of The Dutch Research Council (NWO‐FCB), The EU Joint Programme–Neurodegenerative Disease Research (EU‐JPND), Alzheimer Nederland, Health‐Holland, Topsector Life Sciences & Health, Biogen MA Inc, Boehringer Ingelheim, Life Molecular Imaging, AVID Radiopharmaceuticals, Roche BV, Combinostics, Janssen Stellar, Gieskes Strijbis fonds, and Stichting Equilibrio. Wiesje M van der Flier has performed contract research for Biogen MA Inc and Boehringer Ingelheim and has been an invited speaker at Boehringer Ingelheim and Biogen MA Inc. All funding was paid to the institution. Barbara JH Verhaar, Francisca A de Leeuw, Astrid S Doorduijn, Jay LP Fieldhouse, Ondine van de Rest, Marjolein Visser, Marian AE de van der Schueren, Maartje I Kester, and Majon Muller report no disclosures. Radiology, Brain, Neuroradiology, Multiple Sclerosis Journal Neurology Funding Information: Research of the Alzheimer Center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The clinical database structure was developed with funding from Stichting Dioraphte. Wiesje M van der Flier holds the Pasman chair, is recipient of a donation by stichting Equilibrio, and of a ZonMW Memorabel grant (#733050814). We acknowledge members of the NUDAD project team: Amsterdam University Medical Center —location VUmc: Wiesje van der Flier, Maartje Kester, Philip Scheltens, Charlotte Teunissen, Marian de van der Schueren, Francisca de Leeuw, Astrid Doorduijn, Heleen Hendriksen, Jay Fieldhouse, José Overbeek, Els Dekkers; Vrije Universiteit Amsterdam: Marjolein Visser; Wageningen University & Research: Ondine van de Rest, Sanne Boesveldt; DSM: Peter van‐Dael, Manfred Eggersdorfer; Nutricia Research: John Sijben, Nick van Wijk, Amos Attali, J. Martin Verkuyl, Danielle Counotte; Friesland Campina: Rolf Bos, Cecile Singh‐Povel, Martijn Veltkamp, Ellen van den Heuvel. Publisher Copyright: © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/8/11
Y1 - 2020/8/11
N2 - Introduction: Weight loss is associated with higher mortality and progression of cognitive decline, but its associations with magnetic resonance imaging (MRI) changes related to Alzheimer's disease (AD) are unknown. Methods: We included 412 patients from the NUDAD project, comprising 129 with AD dementia, 107 with mild cognitive impairment (MCI), and 176 controls. Associations between nutritional status and MRI measures were analyzed using linear regression, adjusted for age, sex, education, cognitive functioning, and cardiovascular risk factors. Results: Lower body mass index (BMI), fat mass (FM), and fat free mass index were associated with higher medial temporal atrophy (MTA) scores. Lower BMI, FM, and waist circumference were associated with more microbleeds. Stratification by diagnosis showed that the observed associations with microbleeds were only significant in MCI. Discussion: Lower indicators of nutritional status were associated with more MTA and microbleeds, with largest effect sizes in MCI.
AB - Introduction: Weight loss is associated with higher mortality and progression of cognitive decline, but its associations with magnetic resonance imaging (MRI) changes related to Alzheimer's disease (AD) are unknown. Methods: We included 412 patients from the NUDAD project, comprising 129 with AD dementia, 107 with mild cognitive impairment (MCI), and 176 controls. Associations between nutritional status and MRI measures were analyzed using linear regression, adjusted for age, sex, education, cognitive functioning, and cardiovascular risk factors. Results: Lower body mass index (BMI), fat mass (FM), and fat free mass index were associated with higher medial temporal atrophy (MTA) scores. Lower BMI, FM, and waist circumference were associated with more microbleeds. Stratification by diagnosis showed that the observed associations with microbleeds were only significant in MCI. Discussion: Lower indicators of nutritional status were associated with more MTA and microbleeds, with largest effect sizes in MCI.
KW - body mass index
KW - cerebral atrophy
KW - fat free mass
KW - fat mass
KW - magnetic resonance imaging
KW - malnutrition
KW - microbleeds
KW - mild cognitive impairment
KW - nutritional status
KW - white matter hyperintensities
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090298163&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/32793798
UR - http://www.scopus.com/inward/record.url?scp=85090298163&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/dad2.12063
DO - https://doi.org/10.1002/dad2.12063
M3 - Article
C2 - 32793798
SN - 2352-8729
VL - 12
JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
IS - 1
M1 - e12063
ER -