Oestrogens and bone metabolism: a hypothesis

S. A. Duursma, J. W. Bijlsma, H. C. van Paassen, M. C. Slootweg

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The explanations so far proposed for the effects of oestrogens on bone metabolism in post-menopausal women have been based on the changes seen in calciotrophic hormones. However, we demonstrated in a previous study [6] that there is a decrease in the concentration of somatomedin (an insulin-like growth factor) and an increase in that of growth hormone (GH) in oestrogen-treated post-menopausal women. On the basis of those findings and the relevant data published in the literature, we advance a hypothesis to the effect that the bone-metabolism changes that occur in post-menopausal women following oestrogen replacement therapy come about via changes in serum somatomedin and growth hormone concentrations
Original languageEnglish
Pages (from-to)1-6
Issue number1
Publication statusPublished - 1986

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