Onderzoek naar liquor-diagnostiek bij de ziekte van Alzheimer: een overzicht van de literatuur en van nieuwe ontwikkelingen

W. A. van Gool, P. A. Bolhuis

Research output: Contribution to JournalArticleProfessional

1 Citation (Scopus)


Studies into the value of examination of the cerebrospinal fluid (CSF) in diagnosing Alzheimer's disease are reviewed. The diagnostic utility of about 60 substances including CSF measures related to classical neurotransmitters, (neuro)peptides, proteins, amino-acids, trace elements, and constituents of senile plaques and neurofibrillary tangles is evaluated. Technical, methodological, and ethical issues relevant to this kind of studies are discussed. None of the CSF constituents studies so far, has a proven diagnostic utility. Increased knowledge concerning macromolecular changes in the brain and improved immunochemical techniques make the outlook for a diagnostic test for Alzheimer's disease on CSF promising
Original languageDutch
Pages (from-to)212-216
JournalTijdschrift voor Gerontologie en Geriatrie
Issue number6
Publication statusPublished - 1992

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