TY - JOUR
T1 - Optical biopsy of breast tissue using differential path-length spectroscopy
AU - van Veen, Robert L. P.
AU - Amelink, Arjen
AU - Menke-Pluymers, Marian
AU - van der Pol, Carmen
AU - Sterenborg, Henricus J. C. M.
PY - 2005
Y1 - 2005
N2 - Differential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant breast tissue using a fibre-optic needle probe, and were correlated to the histological outcome of core-needle biopsies taken from the same location as the measurements. DPS yields information on the local tissue blood content, the local blood oxygenation, the average micro-vessel diameter, the beta-carotcne concentration and the scatter slope. Our data show that malignant breast tissue is characterized by a significant decrease in tissue oxygenation and a higher blood content compared to normal breast tissue
AB - Differential path-length spectroscopy (DPS) was used to determine the local optical properties of breast tissue in vivo. DPS measurements were made on healthy and malignant breast tissue using a fibre-optic needle probe, and were correlated to the histological outcome of core-needle biopsies taken from the same location as the measurements. DPS yields information on the local tissue blood content, the local blood oxygenation, the average micro-vessel diameter, the beta-carotcne concentration and the scatter slope. Our data show that malignant breast tissue is characterized by a significant decrease in tissue oxygenation and a higher blood content compared to normal breast tissue
U2 - https://doi.org/10.1088/0031-9155/50/11/009
DO - https://doi.org/10.1088/0031-9155/50/11/009
M3 - Article
C2 - 15901955
SN - 0031-9155
VL - 50
SP - 2573
EP - 2581
JO - Physics in medicine and biology
JF - Physics in medicine and biology
IS - 11
ER -