Optical mammography combined with fluorescence imaging: lesion detection using scatterplots

Anaïs Leproux, Marjolein van der Voort, Martin B. van der Mark, Rik Harbers, Stephanie M. W. Y. van de Ven, Ton G. van Leeuwen

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)


Using scatterplots of 2 or 3 parameters, diffuse optical tomography and fluorescence imaging are combined to improve detectability of breast lesions. Small or low contrast phantom-lesions that were missed in the optical and fluorescence images were detected in the scatterplots. In patient measurements, all tumors were visible and easily differentiated from artifacts and areolas in the scatterplots. The different rate of intake and wash out of the fluorescent contrast agent in the healthy versus malignant tissues was also observed in the scatterplot: this information can be used to discriminate malignant lesion from normal structures. (C) 2011 Optical Society of America
Original languageEnglish
Pages (from-to)1007-1020
JournalBiomedical Optics Express
Issue number4
Publication statusPublished - 2011

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