TY - JOUR
T1 - Optical mammography combined with fluorescence imaging: lesion detection using scatterplots
AU - Leproux, Anaïs
AU - van der Voort, Marjolein
AU - van der Mark, Martin B.
AU - Harbers, Rik
AU - van de Ven, Stephanie M. W. Y.
AU - van Leeuwen, Ton G.
PY - 2011
Y1 - 2011
N2 - Using scatterplots of 2 or 3 parameters, diffuse optical tomography and fluorescence imaging are combined to improve detectability of breast lesions. Small or low contrast phantom-lesions that were missed in the optical and fluorescence images were detected in the scatterplots. In patient measurements, all tumors were visible and easily differentiated from artifacts and areolas in the scatterplots. The different rate of intake and wash out of the fluorescent contrast agent in the healthy versus malignant tissues was also observed in the scatterplot: this information can be used to discriminate malignant lesion from normal structures. (C) 2011 Optical Society of America
AB - Using scatterplots of 2 or 3 parameters, diffuse optical tomography and fluorescence imaging are combined to improve detectability of breast lesions. Small or low contrast phantom-lesions that were missed in the optical and fluorescence images were detected in the scatterplots. In patient measurements, all tumors were visible and easily differentiated from artifacts and areolas in the scatterplots. The different rate of intake and wash out of the fluorescent contrast agent in the healthy versus malignant tissues was also observed in the scatterplot: this information can be used to discriminate malignant lesion from normal structures. (C) 2011 Optical Society of America
U2 - https://doi.org/10.1364/BOE.2.001007
DO - https://doi.org/10.1364/BOE.2.001007
M3 - Article
C2 - 21483622
SN - 2156-7085
VL - 2
SP - 1007
EP - 1020
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 4
ER -