TY - JOUR
T1 - Optimization of Wire-guided Technique With Bracketing Reduces Resection Volumes in Breast-conserving Surgery for Early Breast Cancer
AU - Civil, Yasmin A.
AU - Duvivier, Katya M.
AU - Perin, Paola
AU - Baan, Astrid H.
AU - van der Velde, Susanne
N1 - Publisher Copyright: © 2020 The Authors
PY - 2020/12
Y1 - 2020/12
N2 - Background: Wire-guided localization (WGL) of early breast cancer can be facilitated using multiple wires, which is called bracketing wire-guided localization (BWL). The primary aim of this study is to compare BWL and conventional WGL regarding minimization of resection volumes without compromising margin status. Secondly, BWL is evaluated as an alternative method for intraoperative ultrasound (US) guidance in poorly definable breast tumors on US. Patients and Methods: In this retrospective cohort study, patients with preoperatively diagnosed breast cancer undergoing wide local excision between January 2016 and December 2018 were analyzed. Patients with multifocal disease or neoadjuvant treatment were excluded from this study. Optimal resection with minimal healthy breast tissue removal was assessed using the calculated resection ratio (CRR). Results: BWL was performed in 17 (9%) patients, WGL in 44 (22%), and US in 139 (70%). The rate of negative margins was comparable in all 3 groups. The CRR was significantly smaller for BWL (0.6) than WGL (1.3) in tumors larger than 1.5 cm. Additionally, BWL (0.8) led to smaller CRRs than US (1.7). This could be explained by the high number of small tumors (≤ 1.5 cm) in the US group for which greater CRRs are obtained than for large tumors (> 1.5 cm) (1.9 vs. 1.4; P = .005). Conclusion: For breast tumors larger than 1.5 cm, BWL achieves more optimal resection volumes without compromising margin status compared with WGL. Moreover, BWL seems a suitable alternative to US in patients with poorly ultrasound-visible breast tumors and patients with a small tumor in a (large) breast. Bracketing wire-guided localization (BWL) to demarcate tumor borders can be used to minimize resection volumes in patients with breast cancer. The sample consisted of 17 patients treated with BWL and 44 patients treated with single wire-guided localization. BWL achieved smaller resection volumes than wire-guided localization without compromising margin status for breast tumors larger than 1.5 cm, which could potentially improve cosmetic outcomes.
AB - Background: Wire-guided localization (WGL) of early breast cancer can be facilitated using multiple wires, which is called bracketing wire-guided localization (BWL). The primary aim of this study is to compare BWL and conventional WGL regarding minimization of resection volumes without compromising margin status. Secondly, BWL is evaluated as an alternative method for intraoperative ultrasound (US) guidance in poorly definable breast tumors on US. Patients and Methods: In this retrospective cohort study, patients with preoperatively diagnosed breast cancer undergoing wide local excision between January 2016 and December 2018 were analyzed. Patients with multifocal disease or neoadjuvant treatment were excluded from this study. Optimal resection with minimal healthy breast tissue removal was assessed using the calculated resection ratio (CRR). Results: BWL was performed in 17 (9%) patients, WGL in 44 (22%), and US in 139 (70%). The rate of negative margins was comparable in all 3 groups. The CRR was significantly smaller for BWL (0.6) than WGL (1.3) in tumors larger than 1.5 cm. Additionally, BWL (0.8) led to smaller CRRs than US (1.7). This could be explained by the high number of small tumors (≤ 1.5 cm) in the US group for which greater CRRs are obtained than for large tumors (> 1.5 cm) (1.9 vs. 1.4; P = .005). Conclusion: For breast tumors larger than 1.5 cm, BWL achieves more optimal resection volumes without compromising margin status compared with WGL. Moreover, BWL seems a suitable alternative to US in patients with poorly ultrasound-visible breast tumors and patients with a small tumor in a (large) breast. Bracketing wire-guided localization (BWL) to demarcate tumor borders can be used to minimize resection volumes in patients with breast cancer. The sample consisted of 17 patients treated with BWL and 44 patients treated with single wire-guided localization. BWL achieved smaller resection volumes than wire-guided localization without compromising margin status for breast tumors larger than 1.5 cm, which could potentially improve cosmetic outcomes.
KW - Bracketing wire localization
KW - Breast conservation
KW - Lumpectomy
KW - Ultrasonography
KW - Wide local excision
UR - http://www.scopus.com/inward/record.url?scp=85087700716&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.clbc.2020.04.013
DO - https://doi.org/10.1016/j.clbc.2020.04.013
M3 - Article
C2 - 32653472
SN - 1526-8209
VL - 20
SP - e749-e756
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
IS - 6
ER -