Oral malignant melanoma: A review of the literature

Marco Meleti, C. René Leemans, Wolter J. Mooi, Paolo Vescovi, Isaäc van der Waal

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112 Citations (Scopus)


Primary oral malignant melanoma (OMM) is a rare neoplasm, accounting for 0.5% of all oral malignancies. The etiology is unknown; tobacco use and chronic irritation may play some role. Clinically, OMM may mimick other pigmented lesions. A biopsy is required in order to establish the diagnosis. The reported risk of malignant cells spreading during invasive procedures and factors such as size of the lesion or anatomical limitations, may influence the diagnostic surgical procedure. Therapy of OMM is commonly based on surgical excision of the primary tumour, supplemented by radiotherapy, with chemotherapy and immunotherapy serving as adjuncts. Prognosis is poor, with a 5-year survival rate of approximately 15%.

Original languageEnglish
Pages (from-to)116-121
Number of pages6
JournalOral Oncology
Issue number2
Publication statusPublished - Feb 2007


  • Oral cancer
  • Oral malignant melanoma

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