TY - JOUR
T1 - Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin
AU - Middelkamp-Hup, Maritza A.
AU - Pathak, Madhu A.
AU - Parrado, Concepcion
AU - Goukassian, David
AU - Rius-Díaz, Francisca
AU - Mihm, Martín C.
AU - Fitzpatrick, Thomas B.
AU - González, Salvador
PY - 2004
Y1 - 2004
N2 - BACKGROUND: UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits. Objective We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL). METHODS: A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL-treated and untreated skin. RESULTS: A significant decrease in erythema was found in PL-treated skin (P <.01). Histologically, PL-treated biopsy specimens showed less sunburn cells (P <.05), cyclobutane pyrimidine dimers (P <.001), proliferating epidermal cells (P <.001), and dermal mast cell infiltration (P <.05). A trend toward Langerhans cell preservation was seen. CONCLUSION: Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation
AB - BACKGROUND: UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits. Objective We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL). METHODS: A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL-treated and untreated skin. RESULTS: A significant decrease in erythema was found in PL-treated skin (P <.01). Histologically, PL-treated biopsy specimens showed less sunburn cells (P <.05), cyclobutane pyrimidine dimers (P <.001), proliferating epidermal cells (P <.001), and dermal mast cell infiltration (P <.05). A trend toward Langerhans cell preservation was seen. CONCLUSION: Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation
U2 - https://doi.org/10.1016/j.jaad.2004.06.027
DO - https://doi.org/10.1016/j.jaad.2004.06.027
M3 - Article
C2 - 15583582
SN - 0190-9622
VL - 51
SP - 910
EP - 918
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -