Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: Dental pathologies and osteoradionecrosis (Part 1) literature review and consensus statement

Michela Buglione, Roberta Cavagnini, Federico Di Rosario, Lara Sottocornola, Marta Maddalo, Lucia Vassalli, Salvatore Grisanti, Stefano Salgarello, Ester Orlandi, Corrado Paganelli, Alessandra Majorana, Giorgio Gastaldi, Paolo Bossi, Alfredo Berruti, Giovanni Pavanato, Piero Nicolai, Roberto Maroldi, Andrei Barasch, Elvio G. Russi, Judith Raber-DurlacherBarbara Murphy, Stefano M. Magrini

Research output: Contribution to journalReview articleAcademicpeer-review

77 Citations (Scopus)

Abstract

Radiotherapy alone or in combination with chemotherapy and/or surgery is the typical treatment for head and neck cancer patients. Acute side effects (such as oral mucositis, dermatitis, salivary changes, taste alterations, etc.), and late toxicities in particular (such as osteo-radionecrosis, hypo-salivation and xerostomia, trismus, radiation caries etc.), are often debilitating. These effects tend to be underestimated and insufficiently addressed in the medical community. A multidisciplinary group of head and neck cancer specialists met in Milan with the aim of reaching a consensus on clinical definitions and management of these toxicities. The Delphi Appropriateness method was used for developing the consensus, and external experts evaluated the conclusions. This paper contains 10 clusters of statements about the clinical definitions and management of head and neck cancer treatment sequels (dental pathologies and osteo-radionecroses) that reached consensus, and offers a review of the literature about these topics. The review was split into two parts: the first part dealt with dental pathologies and osteo-radionecroses (10 clusters of statements), whereas this second part deals with trismus and xerostomia
Original languageEnglish
Pages (from-to)131-142
JournalCritical Reviews in Oncology/Hematology
Volume97
DOIs
Publication statusPublished - 2016

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