Abstract
The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3-CD4+CD45+ 'inducer' cells and VCAM1+ICAM1+ stromal 'organizer' cells is presented.
| Original language | English |
|---|---|
| Pages (from-to) | 292-303 |
| Number of pages | 12 |
| Journal | Nature Reviews Immunology |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2003 |
Keywords
- Animals
- CD4-Positive T-Lymphocytes/immunology
- Cell Adhesion Molecules/metabolism
- Chemokines/metabolism
- Humans
- Lymphoid Tissue/embryology
- Lymphotoxin-alpha/metabolism
- Mice
- Mice, Knockout
- Models, Immunological
- Organ Specificity
- T-Lymphocyte Subsets/immunology