Organogenesis of lymphoid tissues

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The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3-CD4+CD45+ 'inducer' cells and VCAM1+ICAM1+ stromal 'organizer' cells is presented.

Original languageEnglish
Pages (from-to)292-303
Number of pages12
JournalNature Reviews Immunology
Issue number4
Publication statusPublished - Apr 2003


  • Animals
  • CD4-Positive T-Lymphocytes/immunology
  • Cell Adhesion Molecules/metabolism
  • Chemokines/metabolism
  • Humans
  • Lymphoid Tissue/embryology
  • Lymphotoxin-alpha/metabolism
  • Mice
  • Mice, Knockout
  • Models, Immunological
  • Organ Specificity
  • T-Lymphocyte Subsets/immunology

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