TY - JOUR
T1 - Oscillatory activity and cortical coherence of the nucleus basalis of Meynert in Parkinson's disease dementia
AU - Nazmuddin, Muhammad
AU - Oterdoom, D. L. Marinus
AU - van Dijk, J. Marc C.
AU - van Zijl, Jonathan C.
AU - Kampman, Anne K.
AU - Drost, Gea
AU - van Laar, Teus
AU - Beudel, Martijn
PY - 2018
Y1 - 2018
N2 - Background: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied. Methods: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM. Measurements were obtained during routine battery replacement. The distance of DBS contacts to the NBM were calculated using CT-MRI fusion. Results: Delta (1–4 Hz) oscillations were more prominently present in the NBM region than in its vicinity, whereas temporal coherence in the theta (4–8 Hz) range was less outspoken. Conclusion: These neurophysiological characteristics, if also proven in larger cohorts, might help to map the NBM more precisely during electrode implantation.
AB - Background: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied. Methods: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM. Measurements were obtained during routine battery replacement. The distance of DBS contacts to the NBM were calculated using CT-MRI fusion. Results: Delta (1–4 Hz) oscillations were more prominently present in the NBM region than in its vicinity, whereas temporal coherence in the theta (4–8 Hz) range was less outspoken. Conclusion: These neurophysiological characteristics, if also proven in larger cohorts, might help to map the NBM more precisely during electrode implantation.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045434588&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29665982
U2 - https://doi.org/10.1016/j.parkreldis.2018.03.024
DO - https://doi.org/10.1016/j.parkreldis.2018.03.024
M3 - Article
C2 - 29665982
SN - 1353-8020
VL - 52
SP - 102
EP - 106
JO - Parkinsonism & Related Disorders
JF - Parkinsonism & Related Disorders
ER -