TY - JOUR
T1 - Overlap of Neuroanatomical Involvement in Frontotemporal Dementia and Primary Psychiatric Disorders
T2 - A Meta-analysis
AU - Ulugut, Hulya
AU - Trieu, Calvin
AU - Groot, Colin
AU - van ’t Hooft, Jochum J.
AU - Tijms, Betty M.
AU - Scheltens, Philip
AU - Ossenkoppele, Rik
AU - Barkhof, Frederik
AU - van den Heuvel, Odile A.
AU - Pijnenburg, Yolande A. L.
N1 - Funding Information: Research of the Alzheimer Centre Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. FB is supported by the National Institute for Health and Care Research Biomedical Research Center at University College London Hospitals. YALP is recipient of the JPND-funded project (FTD-DIPPA). Publisher Copyright: © 2022 Society of Biological Psychiatry
PY - 2022
Y1 - 2022
N2 - Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and each PPD were examined. Results: We found that GMV alterations in the prefrontal and anterior cingulate cortices, temporal lobe, amygdala, and insula comprise the transdiagnostic brain alterations in bvFTD and PPD. Conclusions: Our meta-analysis revealed significant anatomical overlap that paves the way for future investigations of shared pathophysiological pathways, and our cross-disorder approach would provide new insights to better understand the relationship between bvFTD and PPD.
AB - Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and each PPD were examined. Results: We found that GMV alterations in the prefrontal and anterior cingulate cortices, temporal lobe, amygdala, and insula comprise the transdiagnostic brain alterations in bvFTD and PPD. Conclusions: Our meta-analysis revealed significant anatomical overlap that paves the way for future investigations of shared pathophysiological pathways, and our cross-disorder approach would provide new insights to better understand the relationship between bvFTD and PPD.
KW - Autism spectrum disorder
KW - Behavior
KW - Bipolar disorder
KW - Dementia
KW - Frontotemporal dementia
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85136749563&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.biopsych.2022.05.028
DO - https://doi.org/10.1016/j.biopsych.2022.05.028
M3 - Article
C2 - 35965106
SN - 0006-3223
JO - Biological Psychiatry
JF - Biological Psychiatry
ER -