TY - JOUR
T1 - Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients
T2 - A Retrospective Cohort Study
AU - van Son, Jamie
AU - Oussaada, Sabrina M.
AU - Şekercan, Aydin
AU - Beudel, Martijn
AU - Dongelmans, Dave A.
AU - van Assen, Sander
AU - Eland, Ingo A.
AU - Moeniralam, Hazra S.
AU - Dormans, Tom P. J.
AU - van Kalkeren, Colin A. J.
AU - Douma, Renée A.
AU - Rusch, Daisy
AU - Simsek, Suat
AU - Liu, Limmie
AU - Kootte, Ruud S.
AU - Wyers, Caroline E.
AU - IJzerman, Richard G.
AU - van den Bergh, Joop P.
AU - Stehouwer, Coen D. A.
AU - Nieuwdorp, Max
AU - ter Horst, Kasper W.
AU - Serlie, Mireille J.
N1 - Funding Information: This work was supported by a grant from the Corona Research Foundation Amsterdam UMC. Publisher Copyright: Copyright © 2021 van Son, Oussaada, Şekercan, Beudel, Dongelmans, van Assen, Eland, Moeniralam, Dormans, van Kalkeren, Douma, Rusch, Simsek, Liu, Kootte, Wyers, IJzerman, van den Bergh, Stehouwer, Nieuwdorp, ter Horst and Serlie.
PY - 2021/12/14
Y1 - 2021/12/14
N2 - Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19. Design: Retrospective, observational cohort study. Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes. Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients. Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.
AB - Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19. Design: Retrospective, observational cohort study. Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes. Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients. Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.
KW - COVID-19
KW - complications
KW - mortality
KW - obesity
KW - overweight
UR - http://www.scopus.com/inward/record.url?scp=85121972177&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85121972177&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34970220
U2 - https://doi.org/10.3389/fendo.2021.747732
DO - https://doi.org/10.3389/fendo.2021.747732
M3 - Article
C2 - 34970220
SN - 1664-2392
VL - 12
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 747732
ER -