TY - JOUR
T1 - Painful interactions
T2 - Microbial compounds and visceral pain
AU - van Thiel, I. A.M.
AU - Botschuijver, S.
AU - de Jonge, W. J.
AU - Seppen, J.
N1 - Funding Information: This project has received funding from the Ministry of Economic Affairs under TKI-Allowance under the TKI-programme Life Sciences & Health to IAMvT, SB and WJdJ. Funding Information: This project has received funding from the Ministry of Economic Affairs under TKI-Allowance under the TKI-programme Life Sciences & Health to IAMvT, SB and WJdJ. Publisher Copyright: © 2019 The Author(s) Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Visceral pain, characterized by abdominal discomfort, originates from organs in the abdominal cavity and is a characteristic symptom in patients suffering from irritable bowel syndrome, vulvodynia or interstitial cystitis. Most organs in which visceral pain originates are in contact with the external milieu and continuously exposed to microbes. In order to maintain homeostasis and prevent infections, the immune- and nervous system in these organs cooperate to sense and eliminate (harmful) microbes. Recognition of microbial components or products by receptors expressed on cells from the immune and nervous system can activate immune responses but may also cause pain. We review the microbial compounds and their receptors that could be involved in visceral pain development.
AB - Visceral pain, characterized by abdominal discomfort, originates from organs in the abdominal cavity and is a characteristic symptom in patients suffering from irritable bowel syndrome, vulvodynia or interstitial cystitis. Most organs in which visceral pain originates are in contact with the external milieu and continuously exposed to microbes. In order to maintain homeostasis and prevent infections, the immune- and nervous system in these organs cooperate to sense and eliminate (harmful) microbes. Recognition of microbial components or products by receptors expressed on cells from the immune and nervous system can activate immune responses but may also cause pain. We review the microbial compounds and their receptors that could be involved in visceral pain development.
KW - Irritable bowel syndrome
KW - Microbiome
KW - Nociception
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=85074757071&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.bbadis.2019.165534
DO - https://doi.org/10.1016/j.bbadis.2019.165534
M3 - Review article
C2 - 31634534
SN - 0925-4439
VL - 1866
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 1
M1 - 165534
ER -