TY - JOUR
T1 - Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation
AU - Gong, Peijun
AU - Almasian, Mitra
AU - van Soest, Gijs
AU - de Bruin, Daniel
AU - van Leeuwen, Ton
AU - Sampson, David
AU - Faber, Dirk
PY - 2020/4/1
Y1 - 2020/4/1
N2 - SIGNIFICANCE: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT attenuation coefficient and developing them toward clinical applications. AIM: Our review provides an overview of the main models and methods, their assumptions and applicability, together with a survey of preclinical and clinical demonstrations and their translation potential. RESULTS: The use of the attenuation coefficient, particularly when presented in the form of parametric en face images, is shown to be applicable in various medical fields. Most studies show the promise of the OCT attenuation coefficient in differentiating between tissues of clinical interest but vary widely in approach. CONCLUSIONS: As a future step, a consensus on the model and method used for the determination of the attenuation coefficient is an important precursor to large-scale studies. With our review, we hope to provide a basis for discussion toward establishing this consensus.
AB - SIGNIFICANCE: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT attenuation coefficient and developing them toward clinical applications. AIM: Our review provides an overview of the main models and methods, their assumptions and applicability, together with a survey of preclinical and clinical demonstrations and their translation potential. RESULTS: The use of the attenuation coefficient, particularly when presented in the form of parametric en face images, is shown to be applicable in various medical fields. Most studies show the promise of the OCT attenuation coefficient in differentiating between tissues of clinical interest but vary widely in approach. CONCLUSIONS: As a future step, a consensus on the model and method used for the determination of the attenuation coefficient is an important precursor to large-scale studies. With our review, we hope to provide a basis for discussion toward establishing this consensus.
KW - attenuation coefficient
KW - cardiology
KW - dermatology
KW - multiple scattering
KW - oncology
KW - optical coherence tomography
KW - single scattering
UR - http://www.scopus.com/inward/record.url?scp=85083041284&partnerID=8YFLogxK
U2 - https://doi.org/10.1117/1.JBO.25.4.040901
DO - https://doi.org/10.1117/1.JBO.25.4.040901
M3 - Article
C2 - 32246615
SN - 1083-3668
VL - 25
SP - 1
EP - 34
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 4
M1 - 040901
ER -