TY - JOUR
T1 - Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia
AU - Roest, Mark
AU - Rodenburg, Jessica
AU - Wiegman, Albert
AU - Kastelein, John J. P.
AU - Voorbij, Hieronymus A. M.
PY - 2006
Y1 - 2006
N2 - BACKGROUND: Paraoxonase (PON) 1 is a high-density lipoprotein-associated enzyme that may protect against cardiovascular disease. METHOD: We have studied the contribution of PON-1 and PON-2 single nucleotide polymorphisms (SNP; L55M, Q192R and T-107C, S311C) to the intima-media thickness of the common carotid artery in a population of children with classic familial hypercholesterolaemia. RESULTS: The L-variant of the L55M SNP was associated with increased common carotid artery intima-media thickness when compared with the M-variant (P value for trend 0.03). No significant relationship was observed between the other SNP and common carotid artery intima-media thickness. CONCLUSIONS: Our findings suggest that variation at the PON-1 locus contributes to early atherosclerosis in children with familial hypercholesterolaemia
AB - BACKGROUND: Paraoxonase (PON) 1 is a high-density lipoprotein-associated enzyme that may protect against cardiovascular disease. METHOD: We have studied the contribution of PON-1 and PON-2 single nucleotide polymorphisms (SNP; L55M, Q192R and T-107C, S311C) to the intima-media thickness of the common carotid artery in a population of children with classic familial hypercholesterolaemia. RESULTS: The L-variant of the L55M SNP was associated with increased common carotid artery intima-media thickness when compared with the M-variant (P value for trend 0.03). No significant relationship was observed between the other SNP and common carotid artery intima-media thickness. CONCLUSIONS: Our findings suggest that variation at the PON-1 locus contributes to early atherosclerosis in children with familial hypercholesterolaemia
U2 - https://doi.org/10.1097/00149831-200606000-00025
DO - https://doi.org/10.1097/00149831-200606000-00025
M3 - Article
C2 - 16926679
SN - 1741-8267
VL - 13
SP - 464
EP - 466
JO - European journal of cardiovascular prevention and rehabilitation
JF - European journal of cardiovascular prevention and rehabilitation
IS - 3
ER -