Path-length-resolved diffusive particle dynamics in spectral-domain optical coherence tomography

J. Kalkman, R. Sprik, T.G. van Leeuwen

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We describe a new method to measure the decorrelation rate of the optical coherence tomography (OCT) magnitude simultaneously in space and time. We measure the decorrelation rate of the OCT magnitude in a Fourier-domain OCT system for a large range of translational diffusion coefficients by varying the sphere diameter. The described method uses the sensitivity advantage of Fourier-domain OCT over time-domain OCT to increase the particle diffusion imaging speed by a factor of 200. By coherent gating, we reduce the contribution of multiple scattering to the detected signal, allowing a quantitative study of diffusive particle dynamics in high concentration samples. We demonstrate that this technique is well suited to image diffusive particle dynamics in samples with a complex geometry as we measure the morphology and diffusive particle dynamics simultaneously with both high spatial and high temporal resolution.
Original languageEnglish
Pages (from-to)198302
Number of pages4
JournalPhysical Review Letters
Issue number19
Publication statusPublished - 2010


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