Pathogenicity of highly pathogenic avian influenza virus in mammals

Emmie de Wit, Yoshihiro Kawaoka, Menno D. de Jong, Ron A. M. Fouchier

Research output: Contribution to JournalArticleAcademicpeer-review

41 Citations (Scopus)

Abstract

In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here, the current knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity
Original languageEnglish
Pages (from-to)D54-D58
JournalVaccine
Volume26
Issue numberSuppl. 4
DOIs
Publication statusPublished - 2008

Cite this