Patient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor

G van der Werf, F H Menko, J J Gille, P J van Diest, C J van Groeningen

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.

Translated title of the contributionPatient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor
Original languageDutch
Pages (from-to)667-70
Number of pages4
JournalNederlands Tijdschrift voor Geneeskunde
Volume144
Issue number14
Publication statusPublished - 1 Apr 2000

Keywords

  • Adenocarcinoma/etiology
  • Adult
  • Genetic Predisposition to Disease
  • Hamartoma/etiology
  • Humans
  • Intestinal Neoplasms/etiology
  • Liver Neoplasms/etiology
  • Male
  • Neoplasms, Unknown Primary/genetics
  • Peutz-Jeghers Syndrome/complications
  • Thrombophlebitis/etiology

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