TY - CHAP
T1 - Patterns of gene expression during epileptogenesis: Microarray studies in rats
AU - Gorter, J. A.
AU - Lopes da Silva, F. H.
AU - Aronica, E.
PY - 2016
Y1 - 2016
N2 - Microarray experiments with RNA from brain regions obtained at different time points after electrically- or pharmacologically-induced status epilepticus in the rat, point to inflammation as a possible contributing epileptogenic factor. The overwhelming acute inflammatory response is reflected in a general and time dependent activation of multiple genes that code proteases, cytokines and other inflammatory substances. Expression of these genes can alter the dynamics of neuron-glia networks-for example, by potentiating glutamate release from neuronal and glial sources. Some over-activated genes may not only cause parenchymal inflammation but also inflammation of endothelial cells, leading to disruption of the blood brain barrier-a feature that may further contribute to network instability. From this scenario it can be speculated that anti-inflammatory treatment could help to slow down the process of epileptogenesis or prevent further progression of the disease.
AB - Microarray experiments with RNA from brain regions obtained at different time points after electrically- or pharmacologically-induced status epilepticus in the rat, point to inflammation as a possible contributing epileptogenic factor. The overwhelming acute inflammatory response is reflected in a general and time dependent activation of multiple genes that code proteases, cytokines and other inflammatory substances. Expression of these genes can alter the dynamics of neuron-glia networks-for example, by potentiating glutamate release from neuronal and glial sources. Some over-activated genes may not only cause parenchymal inflammation but also inflammation of endothelial cells, leading to disruption of the blood brain barrier-a feature that may further contribute to network instability. From this scenario it can be speculated that anti-inflammatory treatment could help to slow down the process of epileptogenesis or prevent further progression of the disease.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079566599&origin=inward
U2 - https://doi.org/10.1016/B978-0-12-809324-5.00040-7
DO - https://doi.org/10.1016/B978-0-12-809324-5.00040-7
M3 - Chapter
T3 - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
SP - 240
EP - 250
BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PB - Elsevier Science Ltd
ER -