Pch2TRIP13: controlling cell division through regulation of HORMA domains

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During meiotic and mitotic cell divisions, numerous chromosomal processes are essential for the faithful transmission of the genetic material. Pch2TRIP13, a generally conserved member of the AAA+ ATPase (AAA+—ATPases associated with diverse cellular activities) family of ATPases, is rapidly emerging as a key regulator of specific chromosomal events. During the meiotic program, it is involved in controlling G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. Excitingly, recent work has also implicated a role for Pch2TRIP13 in wiring of the checkpoint that guards the metaphase-to-anaphase transition. For several of these functions, the Hop1, Rev7, and Mad2 (HORMA) domain-containing proteins Hop1HORMAD, Mad2, and p31COMET are important downstream clients or cofactors of Pch2TRIP13. Here, I will discuss our current understanding of the function of Pch2TRIP13 during meiotic and mitotic cell divisions, with a focus on its enzymatic role towards HORMA domain-containing clients.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
Issue number3
Publication statusPublished - 26 Sept 2015
Externally publishedYes

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