TY - JOUR
T1 - Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients
T2 - A randomized clinical trial
AU - Van Bokhorst-De Van Der Schueren, M. A.E.
AU - Langendoen, S. I.
AU - Vondeling, H.
AU - Kuik, D. J.
AU - Quak, J. J.
AU - Van Leeuwen, P. A.M.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Background and aims: This study evaluated the use of perioperative nutritional support on Quality of Life (QOL) in malnourished head and neck cancer patients undergoing surgery. Methods: 49 Malnourished (weight loss > 10%) head and neck cancer patients who were included in a nutrition intervention trial were randomized to receive either no preoperative and standard postoperative tube-feeding (group I), standard preoperative and postoperative tube-feeding (group II) or arginine-supplemented preoperative and postoperative tube-feeding (group III). Of these patients, 31 completed a full QOL assessment on the first day of preoperative nutritional support, one day before surgery, and 6 months after surgery. Both a disease-specific (EORTC QLQ-C30) and a generic questionnaire (COOP-WONCA) were used. One way analysis of variance (ANOVA) and the Kruskal-Wallis test were applied for testing differences in scores between groups. Results: Between baseline and the day before surgery, both preoperatively fed groups revealed a positive change for the dimensions physical and emotional functioning and dyspnea (with significance in group II, P = 0.050, 0.031, 0.045 respectively). Group III showed a negative change in appetite (P = 0.049). Between baseline and 6 months after surgery, there were no differences between group I and both pre-fed groups. There were no differences in favour of group III compared to group II. Conclusion: Enteral nutrition improves QOL of severely malnourished head and neck cancer patients in the period preceding surgery. No benefit of preoperative enteral feeding on QOL could be demonstrated 6 months after surgery. (C) 2000 Harcourt Publishers Ltd.
AB - Background and aims: This study evaluated the use of perioperative nutritional support on Quality of Life (QOL) in malnourished head and neck cancer patients undergoing surgery. Methods: 49 Malnourished (weight loss > 10%) head and neck cancer patients who were included in a nutrition intervention trial were randomized to receive either no preoperative and standard postoperative tube-feeding (group I), standard preoperative and postoperative tube-feeding (group II) or arginine-supplemented preoperative and postoperative tube-feeding (group III). Of these patients, 31 completed a full QOL assessment on the first day of preoperative nutritional support, one day before surgery, and 6 months after surgery. Both a disease-specific (EORTC QLQ-C30) and a generic questionnaire (COOP-WONCA) were used. One way analysis of variance (ANOVA) and the Kruskal-Wallis test were applied for testing differences in scores between groups. Results: Between baseline and the day before surgery, both preoperatively fed groups revealed a positive change for the dimensions physical and emotional functioning and dyspnea (with significance in group II, P = 0.050, 0.031, 0.045 respectively). Group III showed a negative change in appetite (P = 0.049). Between baseline and 6 months after surgery, there were no differences between group I and both pre-fed groups. There were no differences in favour of group III compared to group II. Conclusion: Enteral nutrition improves QOL of severely malnourished head and neck cancer patients in the period preceding surgery. No benefit of preoperative enteral feeding on QOL could be demonstrated 6 months after surgery. (C) 2000 Harcourt Publishers Ltd.
KW - Head and neck cancer
KW - Malnutrition
KW - Perioperative nutrition
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=0033669639&partnerID=8YFLogxK
U2 - https://doi.org/10.1054/clnu.2000.0148
DO - https://doi.org/10.1054/clnu.2000.0148
M3 - Article
SN - 0261-5614
VL - 19
SP - 437
EP - 444
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 6
ER -