Peripheral and placental biomarkers in women with placental malaria: a systematic review

Esmée Ruizendaal, Elisabeth van Leeuwen, Petra F. Mens

Research output: Contribution to JournalReview articleAcademicpeer-review

9 Citations (Scopus)


Placental malaria (PM) causes significant morbidity in mothers and infants. Diagnosis of PM during pregnancy is however problematic due to placental sequestration of parasites. Host biomarkers may therefore be used as a diagnostic method. In this systematic review most studies focused on inflammatory markers. A trend was observed for increased IL-10 and TNF- in PM positives. These markers are however unspecific, thus a combination of multiple biomarkers involved in different pathophysiological pathways of PM is indicated. Of interest are inflammatory markers (TNF-R2, CXCL-13), markers of lipid metabolism (APO-B), angiogenesis (sFlt-1) and hormones (estradiol). As the majority of published studies tested biomarker levels only at delivery, more longitudinal cohort studies will be necessary to detect biomarkers during pregnancy that can predict PM
Original languageEnglish
Pages (from-to)217-239
JournalBiomarkers in medicine
Issue number3
Publication statusPublished - 2015

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