Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study

Daniel von Renteln; Karl-Hermann Fuchs; Paul Fockens; Peter Bauerfeind; Melina C. Vassiliou; Yuki B. Werner; Gerald Fried; Wolfram Breithaupt; Henriette Heinrich; Albert J. Bredenoord; Jan F. Kersten; Tessa Verlaan; Michael Trevisonno; Thomas Rösch

doi:https://doi.org/10.1053/j.gastro.2013.04.057

Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study

Daniel von Renteln, Karl-Hermann Fuchs, Paul Fockens, Peter Bauerfeind, Melina C. Vassiliou, Yuki B. Werner, Gerald Fried, Wolfram Breithaupt, Henriette Heinrich, Albert J. Bredenoord, Jan F. Kersten, Tessa Verlaan, Michael Trevisonno, Thomas Rösch

Research output: Contribution to journal › Article › Academic › peer-review

291 Citations (Scopus)

Abstract

Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months

Original language	English
Pages (from-to)	309-11.e1-3
Journal	Gastroenterology
Volume	145
Issue number	2
DOIs	https://doi.org/10.1053/j.gastro.2013.04.057
Publication status	Published - 2013

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https://doi.org/10.1053/j.gastro.2013.04.057

Cite this

von Renteln, D., Fuchs, K.-H., Fockens, P., Bauerfeind, P., Vassiliou, M. C., Werner, Y. B., Fried, G., Breithaupt, W., Heinrich, H., Bredenoord, A. J., Kersten, J. F., Verlaan, T., Trevisonno, M., & Rösch, T. (2013). Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study. Gastroenterology, 145(2), 309-11.e1-3. https://doi.org/10.1053/j.gastro.2013.04.057

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title = "Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study",

abstract = "Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months",

author = "{von Renteln}, Daniel and Karl-Hermann Fuchs and Paul Fockens and Peter Bauerfeind and Vassiliou, {Melina C.} and Werner, {Yuki B.} and Gerald Fried and Wolfram Breithaupt and Henriette Heinrich and Bredenoord, {Albert J.} and Kersten, {Jan F.} and Tessa Verlaan and Michael Trevisonno and Thomas R{\"o}sch",

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von Renteln, D, Fuchs, K-H, Fockens, P, Bauerfeind, P, Vassiliou, MC, Werner, YB, Fried, G, Breithaupt, W, Heinrich, H, Bredenoord, AJ, Kersten, JF, Verlaan, T, Trevisonno, M & Rösch, T 2013, 'Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study', Gastroenterology, vol. 145, no. 2, pp. 309-11.e1-3. https://doi.org/10.1053/j.gastro.2013.04.057

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T1 - Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study

AU - von Renteln, Daniel

AU - Fuchs, Karl-Hermann

AU - Fockens, Paul

AU - Bauerfeind, Peter

AU - Vassiliou, Melina C.

AU - Werner, Yuki B.

AU - Fried, Gerald

AU - Breithaupt, Wolfram

AU - Heinrich, Henriette

AU - Bredenoord, Albert J.

AU - Kersten, Jan F.

AU - Verlaan, Tessa

AU - Trevisonno, Michael

AU - Rösch, Thomas

PY - 2013

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AB - Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months

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DO - https://doi.org/10.1053/j.gastro.2013.04.057

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