Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study

Daniel von Renteln, Karl-Hermann Fuchs, Paul Fockens, Peter Bauerfeind, Melina C. Vassiliou, Yuki B. Werner, Gerald Fried, Wolfram Breithaupt, Henriette Heinrich, Albert J. Bredenoord, Jan F. Kersten, Tessa Verlaan, Michael Trevisonno, Thomas Rösch

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months
Original languageEnglish
Pages (from-to)309-11.e1-3
JournalGastroenterology
Volume145
Issue number2
DOIs
Publication statusPublished - 2013

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