TY - JOUR
T1 - Persistence of parental-reported asthma at early ages
T2 - A longitudinal twin study
AU - Slob, Elise Margaretha Adriana
AU - Longo, Cristina
AU - Vijverberg, Susanne J. H.
AU - Beijsterveldt, Toos C. E. M. van
AU - Bartels, Meike
AU - Hottenga, Jouke Jan
AU - Pijnenburg, Mariëlle W.
AU - Koppelman, Gerard H.
AU - Maitland-van der Zee, Anke-Hilse
AU - Dolan, Conor V.
AU - Boomsma, Dorret I.
N1 - Funding Information: NTR obtained funding from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants including, OCW‐NWO Gravity program‐024.001.003, NWO‐Groot 480‐15‐001/674, and KNAW Academy Professor Award to DIB (PAH/6635); Amsterdam Public Health (APH) research institute. Funding Information: AHM has received research grants outside the submitted work from Lung Foundation of the Netherlands, GSK, Boehringer Ingelheim and VERTEX, she is the PI of a P4O2 (Precision Medicine for more Oxygen) public private partnership sponsored by Health Holland involving many private partners that contribute in cash and/or in kind (Boehringer Ingelheim, Roche Breathomix, Fluidda, Ortec Logiqcare, Philips, Quantib‐U, Smartfish, SODAQ, Thirona, TopMD and Novartis), and she has served in advisory boards for AstraZeneca, GSK and Boehringer Ingelheim with money paid to her institution. G.H. Koppelman reports grants from Lung Foundation of the Netherlands, TEVA the Netherlands, UBBO EMMIUS Foundation, TETRI Foundation, GSK, and VERTEX, outside the submitted work; and G.H. Koppelman participated in a global advisory board on pediatric asthma for GSK and an advisory board meeting to PURE‐IMS. C. Longo, C.E.M. van Beijsterveldt, S.J.H. Vijverberg, D.I. Boomsma, C. Dolan, M. Bartels, J.J. Hottenga, M.W. Pijnenburg and E.M.A. Slob report no conflict of interest for this study. Funding Information: NTR obtained funding from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants including, OCW-NWO Gravity program-024.001.003, NWO-Groot 480-15-001/674, and KNAW Academy Professor Award to DIB (PAH/6635); Amsterdam Public Health (APH) research institute. Publisher Copyright: © 2022 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Background: Currently, we cannot predict whether a pre-school child with asthma-like symptoms will have asthma at school age. Whether genetic information can help in this prediction depends on the role of genetic factors in persistence of pre-school to school-age asthma. We examined to what extent genetic and environmental factors contribute to persistence of asthma-like symptoms at ages 3 to asthma at age 7 using a bivariate genetic model for longitudinal twin data. Methods: We performed a cohort study in monozygotic and dizygotic twins from the Netherlands Twin Register (NTR, n = 21,541 twin pairs). Bivariate genetic models were fitted to longitudinal data on asthma-like symptoms reported by parents at age 3 and 7 years to estimate the contribution of genetic and environmental factors. Results: Bivariate genetic modeling showed a correlation on the liability scale between asthma-like symptoms at age 3 and asthma at age 7 of 0.746 and the contribution of genetics was estimated to be 0.917. The genetic analyses indicated a substantial influence of genetic factors on asthma-like symptoms at ages 3 and 7 (heritability 80% and 90%, respectively); hence, contribution of environmental factors was low. Persistence was explained by a high (rg = 0.807) genetic correlation. Conclusion: Parental-reported asthma-like symptoms at age 3 and asthma at age 7 are highly heritably. The phenotype of asthma-like symptoms at age 3 and 7 was highly correlated and mainly due to heritable factors, indicating high persistence of asthma development over ages 3 and 7.
AB - Background: Currently, we cannot predict whether a pre-school child with asthma-like symptoms will have asthma at school age. Whether genetic information can help in this prediction depends on the role of genetic factors in persistence of pre-school to school-age asthma. We examined to what extent genetic and environmental factors contribute to persistence of asthma-like symptoms at ages 3 to asthma at age 7 using a bivariate genetic model for longitudinal twin data. Methods: We performed a cohort study in monozygotic and dizygotic twins from the Netherlands Twin Register (NTR, n = 21,541 twin pairs). Bivariate genetic models were fitted to longitudinal data on asthma-like symptoms reported by parents at age 3 and 7 years to estimate the contribution of genetic and environmental factors. Results: Bivariate genetic modeling showed a correlation on the liability scale between asthma-like symptoms at age 3 and asthma at age 7 of 0.746 and the contribution of genetics was estimated to be 0.917. The genetic analyses indicated a substantial influence of genetic factors on asthma-like symptoms at ages 3 and 7 (heritability 80% and 90%, respectively); hence, contribution of environmental factors was low. Persistence was explained by a high (rg = 0.807) genetic correlation. Conclusion: Parental-reported asthma-like symptoms at age 3 and asthma at age 7 are highly heritably. The phenotype of asthma-like symptoms at age 3 and 7 was highly correlated and mainly due to heritable factors, indicating high persistence of asthma development over ages 3 and 7.
KW - asthma
KW - asthma-like symptoms
KW - children
KW - discordant twin design
UR - http://www.scopus.com/inward/record.url?scp=85127235324&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/pai.13762
DO - https://doi.org/10.1111/pai.13762
M3 - Article
C2 - 35338742
SN - 0905-6157
VL - 33
SP - 1
EP - 8
JO - Pediatric allergy and immunology
JF - Pediatric allergy and immunology
IS - 3
M1 - e13762
ER -