Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies

Priya Chockalingam; Edgar T. Jaeggi; Lukas A. Rammeloo; Monique C. Haak; Phebe N. Adama van Scheltema; Johannes M. P. J. Breur; Margot M. Bartelings; Sally-Ann B. Clur; Nico A. Blom

doi:https://doi.org/10.3899/jrheum.110720

Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies

Priya Chockalingam, Edgar T. Jaeggi, Lukas A. Rammeloo, Monique C. Haak, Phebe N. Adama van Scheltema, Johannes M. P. J. Breur, Margot M. Bartelings, Sally-Ann B. Clur, Nico A. Blom

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Abstract

To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker. Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement

Original language	English
Pages (from-to)	2682-2685
Journal	Journal of rheumatology
Volume	38
Issue number	12
DOIs	https://doi.org/10.3899/jrheum.110720
Publication status	Published - 2011

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https://doi.org/10.3899/jrheum.110720

Cite this

@article{f8e5ab194bfb4baea86deaf05fd93926,

title = "Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies",

abstract = "To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker. Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement",

author = "Priya Chockalingam and Jaeggi, {Edgar T.} and Rammeloo, {Lukas A.} and Haak, {Monique C.} and {Adama van Scheltema}, {Phebe N.} and Breur, {Johannes M. P. J.} and Bartelings, {Margot M.} and Clur, {Sally-Ann B.} and Blom, {Nico A.}",

year = "2011",

doi = "https://doi.org/10.3899/jrheum.110720",

language = "English",

volume = "38",

pages = "2682--2685",

journal = "Journal of rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "12",

}

TY - JOUR

T1 - Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies

AU - Chockalingam, Priya

AU - Jaeggi, Edgar T.

AU - Rammeloo, Lukas A.

AU - Haak, Monique C.

AU - Adama van Scheltema, Phebe N.

AU - Breur, Johannes M. P. J.

AU - Bartelings, Margot M.

AU - Clur, Sally-Ann B.

AU - Blom, Nico A.

PY - 2011

Y1 - 2011

N2 - To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker. Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement

AB - To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker. Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement

U2 - https://doi.org/10.3899/jrheum.110720

DO - https://doi.org/10.3899/jrheum.110720

M3 - Article

C2 - 22089457

SN - 0315-162X

VL - 38

SP - 2682

EP - 2685

JO - Journal of rheumatology

JF - Journal of rheumatology

IS - 12

ER -