TY - JOUR
T1 - Personality driven alcohol and drug abuse
T2 - New mechanisms revealed
AU - Skóra, Maria Nalberczak
AU - Pattij, Tommy
AU - Beroun, Anna
AU - Kogias, Georgios
AU - Mielenz, Dirk
AU - de Vries, Taco
AU - Radwanska, Kasia
AU - Müller, Christian P.
PY - 2020/9
Y1 - 2020/9
N2 - While the majority of the regular consumers of alcohol controls their consumption well over life span and even takes instrumentalization benefits from it, a minority, but yet high total number of users develops an alcohol addiction. It has long been known that particular personality types are more addiction prone than others. Here we review recent progress in the understanding of neurobiological pathways that determine personality and facilitate drug abuse. Novel approaches to characterize personality traits leading to addiction proneness in social settings in mice are discussed. A common genetic and neurobiological base for the behavioural traits of sensation seeking or a depressed phenotype and escalating alcohol consumption are reviewed. Furthermore, recent progress on how social and cognitive factors, including impulsivity and decision making, act at brain level to make an individual more vulnerable to alcohol abuse, are discussed. Altogether, this review provides an update on brain mechanisms underlying a broad spectrum of personality traits that make an individual more prone to alcohol and drug abuse and addiction.
AB - While the majority of the regular consumers of alcohol controls their consumption well over life span and even takes instrumentalization benefits from it, a minority, but yet high total number of users develops an alcohol addiction. It has long been known that particular personality types are more addiction prone than others. Here we review recent progress in the understanding of neurobiological pathways that determine personality and facilitate drug abuse. Novel approaches to characterize personality traits leading to addiction proneness in social settings in mice are discussed. A common genetic and neurobiological base for the behavioural traits of sensation seeking or a depressed phenotype and escalating alcohol consumption are reviewed. Furthermore, recent progress on how social and cognitive factors, including impulsivity and decision making, act at brain level to make an individual more vulnerable to alcohol abuse, are discussed. Altogether, this review provides an update on brain mechanisms underlying a broad spectrum of personality traits that make an individual more prone to alcohol and drug abuse and addiction.
KW - Addiction
KW - Alcohol
KW - Depression
KW - Drug abuse
KW - Drug instrumentalization
KW - Impulsivity
KW - Personality
KW - Sensation-seeking
UR - http://www.scopus.com/inward/record.url?scp=85086779032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086779032&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neubiorev.2020.06.023
DO - https://doi.org/10.1016/j.neubiorev.2020.06.023
M3 - Review article
C2 - 32565173
SN - 0149-7634
VL - 116
SP - 64
EP - 73
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -