@article{23e94549017b46c98220abf328d6ff86,
title = "Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins",
abstract = "Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response",
author = "{AUTHOR GROUP} and Iris Postmus and Stella Trompet and Deshmukh, {Harshal A.} and Barnes, {Michael R.} and Xiaohui Li and Warren, {Helen R.} and Chasman, {Daniel I.} and Kaixin Zhou and Arsenault, {Benoit J.} and Donnelly, {Louise A.} and Wiggins, {Kerri L.} and Avery, {Christy L.} and Paula Griffin and QiPing Feng and Taylor, {Kent D.} and Guo Li and Evans, {Daniel S.} and Smith, {Albert V.} and {de Keyser}, {Catherine E.} and Johnson, {Andrew D.} and {de Craen}, {Anton J. M.} and Stott, {David J.} and Buckley, {Brendan M.} and Ian Ford and Westendorp, {Rudi G. J.} and Slagboom, {P. Eline} and Naveed Sattar and Munroe, {Patricia B.} and Peter Sever and Neil Poulter and Alice Stanton and Shields, {Denis C.} and Eoin O'Brien and Sue Shaw-Hawkins and Chen, {Y.-D. Ida} and Nickerson, {Deborah A.} and Smith, {Joshua D.} and Dub{\'e}, {Marie Pierre} and Boekholdt, {S. Matthijs} and Hovingh, {G. Kees} and Kastelein, {John J. P.} and McKeigue, {Paul M.} and John Betteridge and Andrew Neil and Durrington, {Paul N.} and Alex Doney and Fiona Carr and Andrew Morris and McCarthy, {Mark I.} and Leif Groop",
year = "2014",
doi = "https://doi.org/10.1038/ncomms6068",
language = "English",
volume = "5",
pages = "5068",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}