TY - JOUR
T1 - Pharmacological approaches to restore mitochondrial function
AU - Andreux, Pénélope A.
AU - Houtkooper, Riekelt H.
AU - Auwerx, Johan
PY - 2013
Y1 - 2013
N2 - Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but also implicated in age-related diseases, including those that affect the metabolic and nervous system, such as type 2 diabetes and Parkinson's disease. Numerous pathways maintain and/or restore proper mitochondrial function, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy and the mitochondrial unfolded protein response. New and powerful phenotypic assays in cell-based models as well as multicellular organisms have been developed to explore these different aspects of mitochondrial function. Modulating mitochondrial function has therefore emerged as an attractive therapeutic strategy for several diseases, which has spurred active drug discovery efforts in this area
AB - Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but also implicated in age-related diseases, including those that affect the metabolic and nervous system, such as type 2 diabetes and Parkinson's disease. Numerous pathways maintain and/or restore proper mitochondrial function, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy and the mitochondrial unfolded protein response. New and powerful phenotypic assays in cell-based models as well as multicellular organisms have been developed to explore these different aspects of mitochondrial function. Modulating mitochondrial function has therefore emerged as an attractive therapeutic strategy for several diseases, which has spurred active drug discovery efforts in this area
U2 - https://doi.org/10.1038/nrd4023
DO - https://doi.org/10.1038/nrd4023
M3 - Review article
C2 - 23666487
SN - 1474-1776
VL - 12
SP - 465
EP - 483
JO - Nature reviews. Drug discovery
JF - Nature reviews. Drug discovery
IS - 6
ER -