Phase II multicenter study of arsenic trioxide, ascorbic acid and dexamethasone in patients with relapsed or refractory multiple myeloma

Ka Lung Wu, Meral Beksac, Jan Van Droogenbroeck, Sergio Amadori, Sonja Zweegman, Pieter Sonneveld

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)


Arsenic trioxide induces growth inhibition and apoptosis in multiple myeloma cell lines. Reducing glutathione by ascorbic acid may enhance the efficacy of arsenic trioxide. Here we report the results of an international multi-center study of arsenic trioxide in combination with ascorbic acid and dexamethasone as treatment for patients with advanced multiple myeloma.
Original languageEnglish
Pages (from-to)1722-1723
Number of pages2
Issue number12
Publication statusPublished - Dec 2006


  • Arsenic trioxide
  • Multiple myeloma
  • Single nucleotide polymorphisms

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