Phasic Flow Patterns of Right versus Left Coronary Arteries in Patients Undergoing Clinical Physiological Assessment

Henry Seligman, Sukhjinder Nijjer, Tim P van de Hoef, Guus A de Waard, Hernán Mejía-Rentería, Mauro Echavarría-Pinto, Matthew J Shun-Shin, James P Howard, Christopher M Cook, Takayuki Warisawa, Yousif Ahmad, Vitaliy Androshchuk, Christopher A Rajkumar, Alexandra Nowbar, Mihir A Kelshiker, Martijn A van Lavieren, Martijn Meuwissen, Ibrahim Danad, Paul Knaapen, Sayan SenRasha Al-Lamee, Jamil Mayet, Javier Escaned, Jan J Piek, Niels van Royen, Justin Davies, Darrel Francis, Ricardo Petraco

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Coronary blood flow in humans is known to be predominantly diastolic. Small studies in animals and humans suggest this is less pronounced or even reversed in the right coronary artery.

AIMS: This study aims to characterise the phasic patterns of coronary flow in the left versus right coronary arteries of patients undergoing invasive physiological assessment.

METHODS: We analysed data from the Iberian-Dutch-English Collaborators (IDEAL) Study. 482 simultaneous pressure and flow measurements from 301 patients were included in our analysis.

RESULTS: On average, coronary flow was higher in diastole both at rest and during hyperaemia both in the RCA and LCA (mean diastolic-to-systolic velocity ratio was, respectively, 1.85±0.70, 1.76±0.58, 1.53±0.34 and 1.58±0.43 for LCArest , LCAhyp , RCArest and RCAhyp , p<0.001 for between vessel comparisons). Although the type of RCA dominance affected the DSVR magnitude (RCAdom = 1.55 ± 0.35, RCAco-dom =1.40 ± 0.27, RCAnon-dom = 1.35, (SD not reported as n=3), systolic flow was very rarely predominant (DSVR was greater than or equal to 1.00 in 472/482 cases (97.9%) overall), with equal prevalence in the LCA. Stenosis severity or microvascular dysfunction had negligible impact on DSVR in both RCA and LCA (DSVR x hyperaemic stenosis resistance R 2 = 0.018, p=0.03 and DSVR x coronary flow reserve R 2 <0.001, p=0.98).

CONCLUSIONS: In patients with CAD undergoing physiological assessment, diastolic flow predominance is seen in both left and right coronary arteries. Clinical interpretation of coronary physiological data should therefore not differ between the left and the right coronary systems.

Original languageEnglish
Publication statusE-pub ahead of print - 3 Aug 2021

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