TY - JOUR
T1 - Photoacoustic determination of blood vessel diameter
AU - Kolkman, Roy G. M.
AU - Klaessens, John H. G. M.
AU - Hondebrink, Erwin
AU - Hopman, Jeroen C. W.
AU - de Mul, Frits F. M.
AU - Steenbergen, Wiendelt
AU - Thijssen, Johan M.
AU - van Leeuwen, Ton G.
PY - 2004
Y1 - 2004
N2 - A double-ring sensor was applied in photoacoustic tomographic imaging of artificial blood vessels as well as blood vessels in a rabbit ear. The peak-to-peak time (tau(pp)) of the laser (1064 nm) induced pressure transient was used to estimate the axial vessel diameter. Comparison with the actual vessel diameter showed that the diameter could be approximated by 2ctau(pp), with c the speed of sound in blood. Using this relation, the lateral diameter could also precisely be determined. In vivo imaging and monitoring of changes in vessel diameters was feasible. Finally, acoustic time traces were recorded while flushing a vessel in the rabbit ear with saline, which proved that the main contribution to the laser-induced pressure transient is caused by blood inside the vessel and that the vessel wall gives only a minor contribution
AB - A double-ring sensor was applied in photoacoustic tomographic imaging of artificial blood vessels as well as blood vessels in a rabbit ear. The peak-to-peak time (tau(pp)) of the laser (1064 nm) induced pressure transient was used to estimate the axial vessel diameter. Comparison with the actual vessel diameter showed that the diameter could be approximated by 2ctau(pp), with c the speed of sound in blood. Using this relation, the lateral diameter could also precisely be determined. In vivo imaging and monitoring of changes in vessel diameters was feasible. Finally, acoustic time traces were recorded while flushing a vessel in the rabbit ear with saline, which proved that the main contribution to the laser-induced pressure transient is caused by blood inside the vessel and that the vessel wall gives only a minor contribution
U2 - https://doi.org/10.1088/0031-9155/49/20/006
DO - https://doi.org/10.1088/0031-9155/49/20/006
M3 - Article
C2 - 15566172
SN - 0031-9155
VL - 49
SP - 4745
EP - 4756
JO - Physics in medicine and biology
JF - Physics in medicine and biology
IS - 20
ER -