TY - JOUR
T1 - Photosensitizer-antibody conjugates for detection and therapy of cancer
AU - Van Dongen, G. A.M.S.
AU - Visser, G. W.M.
AU - Vrouenraets, M. B.
PY - 2004/1/13
Y1 - 2004/1/13
N2 - Photodynamic therapy (PDT) is a promising approach for the treatment of superficially localized tumors. A limitation, however, is the lack of selectivity of the photosensitizers, which can result in severe toxicity. In this overview, the possibilities for using monoclonal antibodies (MAbs) for selective delivery of photosensitizers to tumors, are discussed. This approach is called photoimmunotherapy (PIT). For PIT to be successful, sufficient amounts of sensitizer should be coupled to the MAb without altering its biological properties. A challenging aspect herein is the hydrophobicity of therapeutic photosensitizers. Options for direct and indirect coupling of photosensitizers to MAbs are evaluated, while pros and cons are indicated. Special attention is paid to the quality testing of photoimmunoconjugates, as this information is important for further optimization of PIT. Results obtained thus far with PIT in in vitro and in vivo model systems are discussed. Despite the encouraging progress made, showing the high selectivity of photoimmunoconjugates, PIT still awaits initial clinical evaluation.
AB - Photodynamic therapy (PDT) is a promising approach for the treatment of superficially localized tumors. A limitation, however, is the lack of selectivity of the photosensitizers, which can result in severe toxicity. In this overview, the possibilities for using monoclonal antibodies (MAbs) for selective delivery of photosensitizers to tumors, are discussed. This approach is called photoimmunotherapy (PIT). For PIT to be successful, sufficient amounts of sensitizer should be coupled to the MAb without altering its biological properties. A challenging aspect herein is the hydrophobicity of therapeutic photosensitizers. Options for direct and indirect coupling of photosensitizers to MAbs are evaluated, while pros and cons are indicated. Special attention is paid to the quality testing of photoimmunoconjugates, as this information is important for further optimization of PIT. Results obtained thus far with PIT in in vitro and in vivo model systems are discussed. Despite the encouraging progress made, showing the high selectivity of photoimmunoconjugates, PIT still awaits initial clinical evaluation.
KW - Monoclonal antibody
KW - Photodynamic therapy
KW - Photoimmunoconjugates
KW - Photoimmunotherapy
KW - Tumor targeting
UR - http://www.scopus.com/inward/record.url?scp=0346729780&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.addr.2003.09.003
DO - https://doi.org/10.1016/j.addr.2003.09.003
M3 - Review article
C2 - 14706444
SN - 0169-409X
VL - 56
SP - 31
EP - 52
JO - Advanced drug delivery reviews
JF - Advanced drug delivery reviews
IS - 1
ER -