Physical behavior is weakly associated with physical fatigue in persons with multiple sclerosis-related fatigue

TREFAMS-ACE Study Group

doi:https://doi.org/10.2340/16501977-2375

Physical behavior is weakly associated with physical fatigue in persons with multiple sclerosis-related fatigue

TREFAMS-ACE Study Group

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

BACKGROUND: Fatigue affects 80% of persons with multiple sclerosis and is associated with daily physical functioning. Both fatigue and physical behaviour are multidimensional concepts.

OBJECTIVE: To study the association between the dimensions of physical behaviour and multiple sclerosis-related fatigue.

METHODS: Cross-sectional analysis of 212 persons with multiple sclerosis. Participants were severely fatigued, with a Fatigue Severity Scale median (interquartile range): 5.4 (4.8-5.9) and were minimally to moderately neurologically impaired, based on the Expanded Disability Status Scale: 2.5 (2.0-3.5), 73% had relapsing-remitting multiple sclerosis. Fatigue was measured by questionnaires (i.e. Checklist Individual Strength, Modified Fatigue Impact Scale), and the dimensions subjective, physical, cognitive and psychological fatigue were distinguished. Physical behaviour was measured using an Actigraph GT3X+, and outcomes were categorized into the dimensions of activity amount, activity intensity, day pattern, and distribution of activities.

RESULTS: The physical behaviour dimensions were significantly associated with only the physical fatigue dimension (omnibus F-test: 3.96; df1 = 4, df2 = 207; p = 0.004). Additional analysis showed that the amount of activity (unstandardized beta coefficient (β) = -0.16; 95% confidence interval (CI) -0.27 to -0.04; p = 0.007), activity intensity (β = -0.18; 95% CI -0.31 to -0.06; p = 0.004) and day pattern of activity (β = -0.17; 95% CI, -0.28 to -0.06; p = 0.002) were the physical behaviour dimensions that were significantly associated with physical fatigue.

CONCLUSION: Physical behaviour is weakly associated with physical fatigue and is not associated with other dimensions of fatigue.

Original language	English
Pages (from-to)	821-827
Number of pages	7
Journal	Journal of rehabilitation medicine
Volume	50
Issue number	9
Early online date	5 Sept 2018
DOIs	https://doi.org/10.2340/16501977-2375
Publication status	Published - 1 Oct 2018

Keywords

Fatigue
Multiple sclerosis
Physical behaviour
Rehabilitation

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https://doi.org/10.2340/16501977-2375

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@article{1fe3a063a3cf46b19076ef5738ad5dbe,

title = "Physical behavior is weakly associated with physical fatigue in persons with multiple sclerosis-related fatigue",

abstract = "BACKGROUND: Fatigue affects 80% of persons with multiple sclerosis and is associated with daily physical functioning. Both fatigue and physical behaviour are multidimensional concepts.OBJECTIVE: To study the association between the dimensions of physical behaviour and multiple sclerosis-related fatigue.METHODS: Cross-sectional analysis of 212 persons with multiple sclerosis. Participants were severely fatigued, with a Fatigue Severity Scale median (interquartile range): 5.4 (4.8-5.9) and were minimally to moderately neurologically impaired, based on the Expanded Disability Status Scale: 2.5 (2.0-3.5), 73% had relapsing-remitting multiple sclerosis. Fatigue was measured by questionnaires (i.e. Checklist Individual Strength, Modified Fatigue Impact Scale), and the dimensions subjective, physical, cognitive and psychological fatigue were distinguished. Physical behaviour was measured using an Actigraph GT3X+, and outcomes were categorized into the dimensions of activity amount, activity intensity, day pattern, and distribution of activities.RESULTS: The physical behaviour dimensions were significantly associated with only the physical fatigue dimension (omnibus F-test: 3.96; df1 = 4, df2 = 207; p = 0.004). Additional analysis showed that the amount of activity (unstandardized beta coefficient (β) = -0.16; 95% confidence interval (CI) -0.27 to -0.04; p = 0.007), activity intensity (β = -0.18; 95% CI -0.31 to -0.06; p = 0.004) and day pattern of activity (β = -0.17; 95% CI, -0.28 to -0.06; p = 0.002) were the physical behaviour dimensions that were significantly associated with physical fatigue.CONCLUSION: Physical behaviour is weakly associated with physical fatigue and is not associated with other dimensions of fatigue.",

keywords = "Fatigue, Multiple sclerosis, Physical behaviour, Rehabilitation",

author = "{TREFAMS-ACE Study Group} and Blikman, {Lyan J.M.} and {Van Meeteren}, Jetty and Dimitris Rizopoulos and {De Groot}, V. and Stam, {Henk J.} and Bussmann, {Johannes B.J.} and {De Groot}, V. and A. Malekzadeh and {Van Den Akker}, {L. E.} and M. Looijmans and Sanches, {S. A.} and J. Dekker and Collette, {E. H.} and {Van Oosten}, {B. W.} and Teunissen, {C. E.} and Blankenstein, {M. A.} and Eijssen, {I. C.J.M.} and M. Rietberg and M. Heine and O. Verschuren and G. Kwakkel and Visser-Meily, {J. M.A.} and {Van De Port}, {I. G.L.} and E. Lindeman and Blikman, {L. J.M.} and {Van Meeteren}, J. and Bussmann, {J. B.J.} and Stam, {H. J.} and Hintzen, {R. Q.} and Hacking, {H. G.A.} and Hoogervorst, {E. L.} and Frequin, {S. T.F.M.} and H. Knoop and {De Jong}, {B. A.} and G. Bleijenberg and {De Laat}, {F. A.J.} and Verhulsdonck, {M. C.} and {Van Munster}, Ethl and Oosterwijk, {C. J.} and Aarts, {G. J.} and Heleen Beckerman and H. Beckerman",

year = "2018",

month = oct,

day = "1",

doi = "https://doi.org/10.2340/16501977-2375",

language = "English",

volume = "50",

pages = "821--827",

journal = "Journal of rehabilitation medicine",

issn = "1650-1977",

publisher = "Foundation for Rehabilitation Information",

number = "9",

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TY - JOUR

T1 - Physical behavior is weakly associated with physical fatigue in persons with multiple sclerosis-related fatigue

AU - TREFAMS-ACE Study Group

AU - Blikman, Lyan J.M.

AU - Van Meeteren, Jetty

AU - Rizopoulos, Dimitris

AU - De Groot, V.

AU - Stam, Henk J.

AU - Bussmann, Johannes B.J.

AU - De Groot, V.

AU - Malekzadeh, A.

AU - Van Den Akker, L. E.

AU - Looijmans, M.

AU - Sanches, S. A.

AU - Dekker, J.

AU - Collette, E. H.

AU - Van Oosten, B. W.

AU - Teunissen, C. E.

AU - Blankenstein, M. A.

AU - Eijssen, I. C.J.M.

AU - Rietberg, M.

AU - Heine, M.

AU - Verschuren, O.

AU - Kwakkel, G.

AU - Visser-Meily, J. M.A.

AU - Van De Port, I. G.L.

AU - Lindeman, E.

AU - Blikman, L. J.M.

AU - Van Meeteren, J.

AU - Bussmann, J. B.J.

AU - Stam, H. J.

AU - Hintzen, R. Q.

AU - Hacking, H. G.A.

AU - Hoogervorst, E. L.

AU - Frequin, S. T.F.M.

AU - Knoop, H.

AU - De Jong, B. A.

AU - Bleijenberg, G.

AU - De Laat, F. A.J.

AU - Verhulsdonck, M. C.

AU - Van Munster, Ethl

AU - Oosterwijk, C. J.

AU - Aarts, G. J.

AU - Beckerman, Heleen

AU - Beckerman, H.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - BACKGROUND: Fatigue affects 80% of persons with multiple sclerosis and is associated with daily physical functioning. Both fatigue and physical behaviour are multidimensional concepts.OBJECTIVE: To study the association between the dimensions of physical behaviour and multiple sclerosis-related fatigue.METHODS: Cross-sectional analysis of 212 persons with multiple sclerosis. Participants were severely fatigued, with a Fatigue Severity Scale median (interquartile range): 5.4 (4.8-5.9) and were minimally to moderately neurologically impaired, based on the Expanded Disability Status Scale: 2.5 (2.0-3.5), 73% had relapsing-remitting multiple sclerosis. Fatigue was measured by questionnaires (i.e. Checklist Individual Strength, Modified Fatigue Impact Scale), and the dimensions subjective, physical, cognitive and psychological fatigue were distinguished. Physical behaviour was measured using an Actigraph GT3X+, and outcomes were categorized into the dimensions of activity amount, activity intensity, day pattern, and distribution of activities.RESULTS: The physical behaviour dimensions were significantly associated with only the physical fatigue dimension (omnibus F-test: 3.96; df1 = 4, df2 = 207; p = 0.004). Additional analysis showed that the amount of activity (unstandardized beta coefficient (β) = -0.16; 95% confidence interval (CI) -0.27 to -0.04; p = 0.007), activity intensity (β = -0.18; 95% CI -0.31 to -0.06; p = 0.004) and day pattern of activity (β = -0.17; 95% CI, -0.28 to -0.06; p = 0.002) were the physical behaviour dimensions that were significantly associated with physical fatigue.CONCLUSION: Physical behaviour is weakly associated with physical fatigue and is not associated with other dimensions of fatigue.

AB - BACKGROUND: Fatigue affects 80% of persons with multiple sclerosis and is associated with daily physical functioning. Both fatigue and physical behaviour are multidimensional concepts.OBJECTIVE: To study the association between the dimensions of physical behaviour and multiple sclerosis-related fatigue.METHODS: Cross-sectional analysis of 212 persons with multiple sclerosis. Participants were severely fatigued, with a Fatigue Severity Scale median (interquartile range): 5.4 (4.8-5.9) and were minimally to moderately neurologically impaired, based on the Expanded Disability Status Scale: 2.5 (2.0-3.5), 73% had relapsing-remitting multiple sclerosis. Fatigue was measured by questionnaires (i.e. Checklist Individual Strength, Modified Fatigue Impact Scale), and the dimensions subjective, physical, cognitive and psychological fatigue were distinguished. Physical behaviour was measured using an Actigraph GT3X+, and outcomes were categorized into the dimensions of activity amount, activity intensity, day pattern, and distribution of activities.RESULTS: The physical behaviour dimensions were significantly associated with only the physical fatigue dimension (omnibus F-test: 3.96; df1 = 4, df2 = 207; p = 0.004). Additional analysis showed that the amount of activity (unstandardized beta coefficient (β) = -0.16; 95% confidence interval (CI) -0.27 to -0.04; p = 0.007), activity intensity (β = -0.18; 95% CI -0.31 to -0.06; p = 0.004) and day pattern of activity (β = -0.17; 95% CI, -0.28 to -0.06; p = 0.002) were the physical behaviour dimensions that were significantly associated with physical fatigue.CONCLUSION: Physical behaviour is weakly associated with physical fatigue and is not associated with other dimensions of fatigue.

KW - Fatigue

KW - Multiple sclerosis

KW - Physical behaviour

KW - Rehabilitation

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UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054817073&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30183054

U2 - https://doi.org/10.2340/16501977-2375

DO - https://doi.org/10.2340/16501977-2375

M3 - Article

C2 - 30183054

SN - 1650-1977

VL - 50

SP - 821

EP - 827

JO - Journal of rehabilitation medicine

JF - Journal of rehabilitation medicine

IS - 9

ER -

Physical behavior is weakly associated with physical fatigue in persons with multiple sclerosis-related fatigue

Abstract

Keywords

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