TY - JOUR
T1 - Physical comorbidity in Older-Age Bipolar Disorder (OABD) compared to the general population - a 3-year longitudinal prospective cohort study
AU - Beunders, Alexandra J.M.
AU - Kok, Almar A.L.
AU - Kosmas, Panagiotis C.
AU - Beekman, Aartjan T.F.
AU - Sonnenberg, Caroline M.
AU - Schouws, Sigfried N.T.M.
AU - Kupka, Ralph W.
AU - Stek, Max L.
AU - Dols, Annemiek
N1 - Funding Information: LASA is supported by a grant from the Netherlands Ministry of Health Welfare and Sports, Directorate of Long-Term Care. The data collection in 2012-2013 was financially supported by the Netherlands Organization for Scientific Research (NWO) in the framework of the project “New Cohorts of young old in the 21st century” (file number 480-10-014). The funders had no role in study design; collection, management, analysis, or interpretation of the data; writing of the report. The corresponding author had full access to all the data of both cohort studies and had final responsibility for the decision to submit for publication. The DOBi study did not receive external funding. We thank all DOBi patients and their relatives for their participation. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Background: The aim of this study was to examine the accumulation of chronic physical diseases in Older-Age Bipolar Disorder (OABD) as well as in individuals from the general aging population over a 3-year period. Methods: This prospective longitudinal study compared 101 patients with OABD receiving outpatient care (DOBi cohort) with 2545 individuals from the general aging population (LASA cohort). The presence of eight major chronic diseases was asked at baseline and 3-year follow-up. Total number of diseases was the main outcome measure. Self-rated health (SRH, scale 1-5) was examined as a secondary outcome. Multilevel linear modelling of change was performed to estimate and test the observed change in both samples. Results: At baseline, the number of chronic diseases was lower (b= -0.47, p<0.01) and self-rated health comparable (b=0.27, p=0.13) in DOBi than in LASA. Over 3 years the number of chronic diseases increased faster in DOBi than in LASA (b=0.51 versus b=0.35, p(interaction)=0.03). When corrected for employment, depressive symptoms, waist circumference, smoking, and alcohol use, this difference was no longer significant. SRH decreased faster in DOBi than in LASA (b=-0.24 versus b=-0.02, p(interaction)=0.04). Limitations: Information on chronic diseases was collected using self-report. Conclusions: A faster accumulation of chronic physical diseases and a faster decline in health perception was observed in OABD than in participants from the general population. The observed differences could partly be attributed to baseline differences in psychosocial, lifestyle, and health behaviour factors. Our findings urgently call for the use of integrated care in BD.
AB - Background: The aim of this study was to examine the accumulation of chronic physical diseases in Older-Age Bipolar Disorder (OABD) as well as in individuals from the general aging population over a 3-year period. Methods: This prospective longitudinal study compared 101 patients with OABD receiving outpatient care (DOBi cohort) with 2545 individuals from the general aging population (LASA cohort). The presence of eight major chronic diseases was asked at baseline and 3-year follow-up. Total number of diseases was the main outcome measure. Self-rated health (SRH, scale 1-5) was examined as a secondary outcome. Multilevel linear modelling of change was performed to estimate and test the observed change in both samples. Results: At baseline, the number of chronic diseases was lower (b= -0.47, p<0.01) and self-rated health comparable (b=0.27, p=0.13) in DOBi than in LASA. Over 3 years the number of chronic diseases increased faster in DOBi than in LASA (b=0.51 versus b=0.35, p(interaction)=0.03). When corrected for employment, depressive symptoms, waist circumference, smoking, and alcohol use, this difference was no longer significant. SRH decreased faster in DOBi than in LASA (b=-0.24 versus b=-0.02, p(interaction)=0.04). Limitations: Information on chronic diseases was collected using self-report. Conclusions: A faster accumulation of chronic physical diseases and a faster decline in health perception was observed in OABD than in participants from the general population. The observed differences could partly be attributed to baseline differences in psychosocial, lifestyle, and health behaviour factors. Our findings urgently call for the use of integrated care in BD.
KW - Aging
KW - Bipolar Disorder
KW - Chronic Illness
KW - Comorbidity
KW - Geriatric Psychiatry
KW - NCDs
KW - Noncommunicable diseases
KW - Older-Age Bipolar Disorder
UR - http://www.scopus.com/inward/record.url?scp=85103770651&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jad.2021.03.057
DO - https://doi.org/10.1016/j.jad.2021.03.057
M3 - Article
C2 - 33845328
SN - 0165-0327
VL - 288
SP - 83
EP - 91
JO - Journal of affective disorders
JF - Journal of affective disorders
ER -