TY - JOUR
T1 - Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women
AU - Arsenault, B. J.
AU - Rana, J. S.
AU - Lemieux, I.
AU - Després, J.-P.
AU - Kastelein, J. J. P.
AU - Boekholdt, S. M.
AU - Wareham, N. J.
AU - Khaw, K.-T.
PY - 2010
Y1 - 2010
N2 - Objective: To test the hypothesis that for any given body mass index (BMI) category, active individuals would have a smaller waist circumference than inactive individuals. Our second objective was to examine the respective contribution of waist circumference and physical inactivity on coronary heart disease (CHD) risk. Design: Prospective, population-based study with an 11.4-year follow-up. Subjects: A total of 21 729 men and women aged 45-79 years, residing in Norfolk, UK. Methods: During follow-up, 2191 CHD events were recorded. Physical activity was evaluated using a validated lifestyle questionnaire that takes into account both leisure-time and work-related physical activity. Waist circumference was measured and BMI was calculated for each participant. Results: For both men and women, we observed that within each BMI category ( <25.0, 25-30 and >= 30.0 kg m(-2)), active participants had a lower waist circumference than inactive participants (P <0.001). In contrast, within each waist circumference tertile, BMI did not change across physical activity categories ( except for women with an elevated waist circumference). Compared with active men with a low waist circumference, inactive men with an elevated waist circumference had a hazard ratio (HR) for future CHD of 1.74 (95% confidence interval (CI), 1.34-2.27) after adjusting for age, smoking, alcohol intake and parental history of CHD. In the same model and after further adjusting for hormone replacement therapy use, compared with active women with a low waist circumference, inactive women with an elevated waist circumference had an HR for future CHD of 4.00 ( 95% CI, 2.04-7.86). Conclusion: In any BMI category, inactive participants were characterized by an increased waist circumference, a marker of abdominal adiposity, compared with active individuals. Physical inactivity and abdominal obesity were both independently associated with an increased risk of future CHD. International Journal of Obesity ( 2010) 34, 340-347; doi: 10.1038/ijo.2009.229; published online 17 November 2009
AB - Objective: To test the hypothesis that for any given body mass index (BMI) category, active individuals would have a smaller waist circumference than inactive individuals. Our second objective was to examine the respective contribution of waist circumference and physical inactivity on coronary heart disease (CHD) risk. Design: Prospective, population-based study with an 11.4-year follow-up. Subjects: A total of 21 729 men and women aged 45-79 years, residing in Norfolk, UK. Methods: During follow-up, 2191 CHD events were recorded. Physical activity was evaluated using a validated lifestyle questionnaire that takes into account both leisure-time and work-related physical activity. Waist circumference was measured and BMI was calculated for each participant. Results: For both men and women, we observed that within each BMI category ( <25.0, 25-30 and >= 30.0 kg m(-2)), active participants had a lower waist circumference than inactive participants (P <0.001). In contrast, within each waist circumference tertile, BMI did not change across physical activity categories ( except for women with an elevated waist circumference). Compared with active men with a low waist circumference, inactive men with an elevated waist circumference had a hazard ratio (HR) for future CHD of 1.74 (95% confidence interval (CI), 1.34-2.27) after adjusting for age, smoking, alcohol intake and parental history of CHD. In the same model and after further adjusting for hormone replacement therapy use, compared with active women with a low waist circumference, inactive women with an elevated waist circumference had an HR for future CHD of 4.00 ( 95% CI, 2.04-7.86). Conclusion: In any BMI category, inactive participants were characterized by an increased waist circumference, a marker of abdominal adiposity, compared with active individuals. Physical inactivity and abdominal obesity were both independently associated with an increased risk of future CHD. International Journal of Obesity ( 2010) 34, 340-347; doi: 10.1038/ijo.2009.229; published online 17 November 2009
U2 - https://doi.org/10.1038/ijo.2009.229
DO - https://doi.org/10.1038/ijo.2009.229
M3 - Article
C2 - 19918249
SN - 0307-0565
VL - 34
SP - 340
EP - 347
JO - International journal of obesity (2005)
JF - International journal of obesity (2005)
IS - 2
ER -