Pilot of a therapist-guided digital mental health intervention (eHealth CF-CBT) for adults with cystic fibrosis

Marieke Verkleij, Anna M. Georgiopoulos, Heleen Barendrecht, Deborah Friedman

Research output: Contribution to journalArticleAcademicpeer-review


Background: eHealth CF-CBT is the first digital mental health intervention for depression/anxiety in adults with cystic fibrosis (awCF); an 8-session therapist-guided internet-delivered program that was developed in English and Dutch with stakeholder input and evaluation indicating high acceptability and usability. Methods: Dutch eHealth CF-CBT was piloted in awCF with mild-moderate symptoms of depression and/or anxiety. Feasibility, usability, acceptability, and preliminary efficacy were assessed, measuring pre-post changes in depression (PHQ-9), anxiety (GAD-7), perceived stress (PSS), and health-related quality of life (CFQ-R). Results: All participants (n = 10, seven female, mean age 29 [range 21–43], mean FEV1 71%pred [range 31–115]) completed all sessions. Patient-rated feasibility, usability, and acceptability of eHealth CF-CBT were positive on validated scales, as were qualitative assessments of content and format. GAD-7 improved in 90% of participants; in 50% by ≥the minimally important difference (MID) of four points. PHQ-9 improved in 90%; 40% by ≥the MID of 5. PSS improved in 80%. CFQ-R improved in the domain health perceptions (70%). Conclusions: eHealth CF-CBT demonstrated feasibility, usability, acceptability, and promising preliminary efficacy in this pilot trial with Dutch awCF with mild to moderate symptoms of depression and anxiety.
Original languageEnglish
Pages (from-to)2094-2103
Number of pages10
JournalPediatric pulmonology
Issue number7
Early online date2023
Publication statusPublished - Jul 2023


  • anxiety
  • cognitive-behavioral therapy
  • cystic fibrosis
  • depression
  • digital mental health
  • psychotherapy

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