Plasma dimethylarginine levels in chronic hemodialysis patients are independent of the type of dialyzer applied.

M.P. Grooteman, I.M. Wauters, T. Teerlink, J.W.R. Twisk, M.J. Nube

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)


Background: Asymmetric dimethylarginine (ADMA) levels are increased in hemodialysis (HD) patients. Reports on the effect of various dialysis strategies on ADMA, symmetric dimethylarginine (SDMA) and L-arginine levels are inconclusive. Patients/Methods: In this randomized crossover study, 15 patients were dialyzed for 4 weeks with 4 dialyzers, differing in biocompatibility and flux. Dimethylarginine and L-arginine levels were assessed at baseline, and after 4 weeks both before and after HD. Results: During HD, ADMA and SDMA levels decreased significantly with all dialyzers. Dimethylarginine and L-arginine levels remained stable after 4 weeks of HD with each membrane. After pooling all data, values were mainly explained by variation between time points and patients, not by the type of dialyzer. Conclusion: Despite an intradialytic decrease in dimethylarginines, no changes occurred after 4 weeks of HD with either membrane. Furthermore, the variability of AMDA, SDMA and L-arginine levels was far more dependent on patient-related factors than on the type of dialyzer applied. Copyright © 2007 S. Karger AG.
Original languageEnglish
Pages (from-to)281-289
Number of pages9
JournalBlood Purification
Issue number3
Publication statusPublished - 2007


  • Adult
  • Aged
  • Aged, 80 and over
  • Arginine/analogs & derivatives
  • Biocompatible Materials
  • Complement C3a/analysis
  • Cross-Over Studies
  • Equipment Design
  • Female
  • Humans
  • Kidney Failure, Chronic/blood
  • Male
  • Membranes, Artificial
  • Middle Aged
  • Nitric Oxide/metabolism
  • Prospective Studies
  • Renal Dialysis/instrumentation
  • beta 2-Microglobulin/analysis

Cite this